Multiple orale Papeln und Plaques bei einem Patienten mit Morbus Crohn^[*]

Zusammenfassung

Bei einem 55-jährigen Patienten traten innerhalb eines Jahres multiple, teils pflastersteinartig imponierende, asymptomatische Papeln an Zunge, Lippen- undWangenschleimhaut auf. Der Patient wurde wegen eines M. Crohn mit Azathioprin und Glukokortikoiden behandelt. Histologisch zeigte sich eine akanthotisch verbreiterte Plattenepithelhyperplasie mit Virus-assoziierten Epithelveränderungen. Unter der Diagnose einer oralen fokalen epithelialen Hyperplasie (Morbus Heck) wurden die Papeln, nach erfolgloser Anwendung von Imiquimod-Creme, mittels CO₂-Laser erfolgreich vaporisiert.

Abstract

A 55-year old male developed multiple in part cobblestone-like asymptomatic papules at the tongue, the lips, and buccal mucosa. His Crohn’s disease had been treated with azathioprine and glucocorticoids. The histology revealed an acanthotic squamous cell hyperplasia with classical virus-associated epithelial changes. After the clinical diagnosis and the ineffective trial of therapy with Imiquimod, a CO₂-laser treatment was performed successfully.

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