Wirksamkeit von Ceftarolin bei komplizierten Haut- und Weichgewebeinfektionen

Schlüsselwörter

komplizierte Haut- und Weichgewebeinfektion (cSSTI) - CANVAS 1, CANVAS 2 - Ceftarolin - Vancomycin/Aztreonam

Keywords

complicated skin and soft tissue infection (cSSTI) - CANVAS 1, CANVAS 2 - ceftaroline - vancomycin/aztreonam

• Literatur

• 1 AMR Hospital Antibiotic Market Guide – Book 2. Diagnosis and Surgery Reports . Januar 2010–Juni 2010
• 2 Corey GR, Wilcox M, Talbot GH et al. Integrated analysis of CANVAS 1 and 2: phase 3, multicenter, randomized, double-blind studies to evaluate the safety and efficacy of ceftaroline versus vancomycin plus aztreonam in complicated skin and skin-structure infection. Clin Infect Dis 2010; 51: 641-650
• 3 Corey GR, Wilcox MH, Talbot GH et al. CANVAS 1: the first Phase III, randomized, double-blind study evaluating ceftaroline fosamil for the treatment of patients with complicated skin and skin structure infections. J Antimicrob Chemother 2010; 65 (Suppl. 04) iv41-iv51
• 4 Friedland HD, O'Neal T, Biek D et al. CANVAS 1 and 2: analysis of clinical response at day 3 in two phase 3 trials of ceftaroline fosamil versus vancomycin plus aztreonam in treatment of acute bacterial skin and skin structure infections. Antimicrob Agents Chemother 2012; 56: 2231-2236
• 5 Kumar A, Ellis P, Arabi Y et al. Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock. Chest 2009; 136: 1237-1248
• 6 Szumowski JD, Cohen DE, Kanaya F et al. Treatment and outcomes of infections by methicillin-resistant Staphylococcus aureus at an ambulatory clinic. Antimicrob Agents Chemother 2007; 51: 423-428
• 7 Wilcox MH, Corey GR, Talbot GH et al. CANVAS 2: the second Phase III, randomized, double-blind study evaluating ceftaroline fosamil for the treatment of patients with complicated skin and skin structure infections. J Antimicrob Chemother 2010; 65 (Suppl. 04) iv53-iv65