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Pharmacopsychiatry 2014; 47(02): 73-78
DOI: 10.1055/s-0034-1371867
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

The Influence of 8 and 16 mg Nicotine Patches on Sleep in Healthy Non-Smokers

A. Jaehne
1   Department of Psychiatry and Psychotherapy, Freiburg University Medical Center, Freiburg, Germany
,
T. Unbehaun
1   Department of Psychiatry and Psychotherapy, Freiburg University Medical Center, Freiburg, Germany
,
B. Feige
1   Department of Psychiatry and Psychotherapy, Freiburg University Medical Center, Freiburg, Germany
,
S. Herr
1   Department of Psychiatry and Psychotherapy, Freiburg University Medical Center, Freiburg, Germany
,
A. Appel
1   Department of Psychiatry and Psychotherapy, Freiburg University Medical Center, Freiburg, Germany
,
D. Riemann
1   Department of Psychiatry and Psychotherapy, Freiburg University Medical Center, Freiburg, Germany
› Author Affiliations
Further Information

Publication History

received 15 September 2013
revised 12 February 2014

accepted 19 February 2014

Publication Date:
31 March 2014 (online)

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Corrected by:

The Influence of 8 and 16 mg Nicotine Patches on Sleep in Healthy Non-SmokersPharmacopsychiatry 2015; 48(07): 291-291
DOI: 10.1055/s-0035-1564198

Abstract

Aim and Methods:

The purpose of this study was to determine whether sleep changes are a consequence of nicotine presence or withdrawal during the night, we examined 66 healthy non-smokers (33 males, 33 females, age: 20–25 years) after an adaptation night in a sleep laboratory setting. Subjects were randomized to receive placebo or either 8 or 16 mg nicotine patches during the day or during the night in a double blind, parallel group design.

Results:

The 16 mg nicotine patch applied during the night caused a reduced sleep period time and sleep efficiency as well as an increased wake time. A reduced REM-sleep latency and subjective sleep quality rating were found in subjects receiving nicotine during the night. Arousals, apneas and periodic leg movements were not affected by nicotine.

Discussion:

This study documents insomnia-like sleep changes in healthy non-smokers caused by nicotine in a dose-dependent manner. There was no evidence for sleep-related withdrawal symptoms after 13 h of nicotine application.

Key words

sleep - insomnia - smoking - nicotine - leg movements
 

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