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Semin Neurol 2014; 34(01): 047-060
DOI: 10.1055/s-0034-1372342
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

New Approaches to the Diagnosis and Treatment of Cryptococcal Meningitis

Azure T. Makadzange
1   Department of Ragon Institute of MGH, MIT and Harvard, Medicine Harvard Medical School, Boston, Massachusetts
2   Department of Medicine, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe
,
Grace McHugh
3   Department of Medicine, Parirenyatwa Hospital Family Care Centre, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe
› Author Affiliations
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Publication History

Publication Date:
08 April 2014 (online)

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Abstract

Cryptococcal meningitis remains one of the leading causes of morbidity and mortality among immunosuppressed individuals, particularly those with advanced acquired immunodeficiency syndrome. The greatest burden of disease is in sub-Saharan Africa and Asia where there is limited access to diagnostics and treatment for the disease. The authors review the available tools for diagnosing cryptococcal meningitis and review treatment for cryptococcal meningitis, highlighting the evidence behind current treatment guidelines.

Keywords

cryptococcal meningitis - human immunodeficiency virus - acquired immunodeficiency syndrome - sub-Saharan Africa
 

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