Open Access
J Neurol Surg Rep 2014; 75(02): e194-e199
DOI: 10.1055/s-0034-1372472
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Synchronous Esthesioneuroblastoma and Growth-Hormone-Secreting Pituitary Macroadenoma: Combined Open and Endoscopic Management

Authors

  • Costanza J. Valdes

    1   Department of Otolaryngology – Head and Neck Surgery, McGill University, Jewish General Hospital, Montreal, Quebec, Canada
  • Marc A. Tewfik

    1   Department of Otolaryngology – Head and Neck Surgery, McGill University, Jewish General Hospital, Montreal, Quebec, Canada
  • Marie-Christine Guiot

    2   Department of Neuropathology, McGill University, Montreal Neurological Institute, Montreal, Quebec, Canada
  • Salvatore Di Maio

    3   Division of Neurosurgery, McGill University, Jewish General Hospital, Montreal, Quebec, Canada
Further Information

Publication History

18 June 2013

24 January 2014

Publication Date:
21 July 2014 (online)

Preview

Abstract

Background Esthesioneuroblastoma is an uncommon malignant neoplasm that arises from the olfactory neuroepithelium. In this article we report a case of esthesioneuroblastoma presenting concomitantly with a growth-hormone (GH)-secreting pituitary macroadenoma.

Results A 52 year old woman underwent surgery for suspected nasal polyps. Intralesional debulking of an intranasal tumor disclosed a low-grade esthesioneuroblastoma. Magnetic resonance imaging (MRI) demonstrated a large nasal and intracranial tumor, in addition to a separate sellar and suprasellar tumor. The patient was frankly acromegalic. She underwent a first-stage gross total resection of the esthesioneuroblastoma via a combined extended subfrontal and extended endonasal approach, followed by focused radiation therapy. She then returned for endoscopic removal of the GH-secreting pituitary macroadenoma.

Conclusion The combined open and endoscopic management of this patient is described and a review of the literature presented. To our knowledge this is the first case of synchronous esthesioneuroblastoma and macroadenoma, in this case GH secreting, described in the literature.

Note

Salvatore Di Maio had full access to all the data in the study and final responsibility for the decision to submit for publication.