Horm Metab Res 2015; 47(03): 232-238
DOI: 10.1055/s-0034-1376990
Endocrine Care
© Georg Thieme Verlag KG Stuttgart · New York

DASH Diet, Insulin Resistance, and Serum hs-CRP in Polycystic Ovary Syndrome: A Randomized Controlled Clinical Trial

Z. Asemi
1  Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
A. Esmaillzadeh
2  Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
3  Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
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received 16. Januar 2014

accepted 05. Mai 2014

23. Juni 2014 (online)


This study was designed to assess the effects of Dietary Approaches to Stop Hypertension (DASH) eating plan on insulin resistance and serum hs-CRP in overweight and obese women with PCOS. This randomized controlled clinical trial was done on 48 women diagnosed with PCOS. Subjects were randomly assigned to consume either the control (n=24) or the DASH eating pattern (n=24) for 8 weeks. The DASH diet consisted of 52% carbohydrates, 18% proteins, and 30% total fats. It was designed to be rich in fruits, vegetables, whole grains, and low-fat dairy products and low in saturated fats, cholesterol, refined grains, and sweets. Sodium content of the DASH diet was designed to be less than 2 400 mg/day. The control diet was also designed to contain 52% carbohydrates, 18% protein, and 30% total fat. Fasting blood samples were taken at baseline and after 8 weeks intervention to measure ­insulin resistance and serum hs-CRP levels. ­Adherence to the DASH eating pattern, compared to the ­control diet, resulted in a significant reduction of serum insulin levels (−1.88 vs. 2.89 μIU/ml, p=0.03), HOMA-IR score (−0.45 vs. 0.80; p=0.01), and serum hs-CRP levels (−763.29 vs. 665.95 ng/ml, p=0.009). Additionally, a significant reduction in waist (−5.2 vs. −2.1 cm; p=0.003) and hip circumference (−5.9 vs. −1 cm; p<0.0001) was also seen in the DASH group compared with the control group. In conclusion, consumption of the DASH eating pattern for 8 weeks in overweight and obese women with PCOS resulted in the improvement of insulin resistance, serum hs-CRP levels, and abdominal fat accumulation.

Clinical trial registration number: www.irct.ir: IRCT201304235623N6