Synthesis of 2-Alkynyl 1,3,4-Oxadiazoles by Palladium-Catalyzed Cross- Coupling Reaction^[1]

Abstract

Several 2-alkynyl 1,3,4-oxadiazoles have been synthesized efficiently by employing palladium-catalyzed cross-coupling under Sonogashira reaction conditions. This reaction has been applied for the first time for the preparation of oxadiazole derivatives. The products were formed in high yields and no side products were detected.

Key words

1,3,4-oxadiazole - Sonogashira coupling - palladium-catalyzed reaction - copper(I) iodide - alkynylation

• References and Notes

• 1 Part 236 in the series ‘Studies on novel synthetic methodologies’.
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