Friedel–Crafts Cyclodehydration Approach toward the Synthesis of Ellipti-cine and 9-Methoxyellipticine

Abstract

An expedient synthesis of biologically important pyrido[4,3-b]carbazole alkaloids, ellipticine and 9-methoxyellipticine, is reported. Our synthetic approach applies a key H₃PO₄-mediated Friedel–Crafts cyclodehydration to construct the pyridine core.

Key words

alkaloids - nitrogen heterocycles - natural products - total synthesis - cyclization

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• 14 The CCDC deposition number for compound 19 is 994825. Formula: C₂₄H₂₀N₂. Unit cell parameters: a = 15.225 (8), b = 5.364 (3), c = 22.108 (12), α = 90, β = 101.789 (9), γ = 90, Space group P21/c.