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Pädiatrie up2date 2015; 10(02): 179-192
DOI: 10.1055/s-0034-1391977
Hämatologie/Onkologie
© Georg Thieme Verlag KG Stuttgart · New York

Eisenmangelanämie und Eisenstoffwechselstörungen

Stefan W. Eber
,
Lena A. Machetanz
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Publication Date:
29 May 2015 (online)

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Fazit

Derzeit ist die Sicherheit und Effizienz einer Langzeittherapie mit einer Kombination mit Deferoxamin oder Deferasirox und Deferipron noch nicht hinreichend belegt, sodass diese Behandlung nur in hämatologischen Zentren mit jahrelanger Erfahrung in der Thalassämie-Therapie und im Rahmen einer klinischen Studie angewandt werden sollte. Auf mögliche Medikamentennebenwirkungen, wie verstärkte Hämolyse, Agranulozytose und Gelenkschäden, sollte besonders geachtet werden.

 

  • Literatur

  • 1 Halterman JS, Kaczorowski JM, Aligne CA et al. Iron Deficiency and Cognitive Achievement Among School-Aged Children and Adolescents in the United States. Pediatrics 2001; 107: 1381-1386
    CrossrefGoogle Scholar
  • 2 Aggett PJ, Agostoni C, Axelsson I et al. Iron metabolism and requirements in early childhood: do we know enough? a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr 2002; 34 : 337-345
    CrossrefGoogle Scholar
  • 3 Iolascon A, De Falco L, Beaumont C. Molecular basis of inherited microcytic anemia due to defects in iron acquisition or heme synthesis. Haematologica 2009; 94 : 395-408
    CrossrefGoogle Scholar
  • 4 Muckenthaler MU. Fine Tuning of Hepcidin Expression by Positive and Negative Regulators. Cell Metabolism 2008; 8: 1-3
    CrossrefGoogle Scholar
  • 5 Du X, She E, Gelbart T et al. The serine protease TMPRSS6 is required to sense iron deficiency. Science 2008; 320: 1088-1092
    CrossrefGoogle Scholar
  • 6 Andrews NC. Forging a field: the golden age of iron biology. Blood 2008; 15: 219-230
    Google Scholar
  • 7 Guillem F, Lawson S, Kannengiesser C et al. Two nonsense mutations in the TMPRSS6 gene in a patient with microcytic anaemia and iron deficiency. Blood 2009; 113 : 5605-5608
    CrossrefGoogle Scholar
  • 8 Behnisch W, Muckenthaler M, Kulozik A. Eisenmangelanämie. http://www.awmf.org/leitlinien/detail/ll/025-021.html
    Google Scholar
  • 9 Kulozik AE, Kunz J. Anämiediagnostik im Kindesalter. Leitlinie der Gesellschaft für pädiatrische Onkologie und Hämatologie. http://www.awmf.org/leitlinien/detail/ll/025-027.html
    Google Scholar
  • 10 Van Wyck DB, Mangione A, Morrison J et al. BLOOD MANAGEMENT: Large-dose intravenous ferric carboxymaltose injection for iron deficiency anemia in heavy uterine bleeding: a randomized, controlled trial. Transfusion 2009; 49: 2719-2728
    CrossrefGoogle Scholar
  • 11 Bansal D et al. Serodiagnosis of celiac disease in children referred for evaluation of anemia: a pediatric hematology unit’s experience. Indian J Pathol Microbiol 2011; 54: 756-760
    Google Scholar
  • 12 Husby S, Koletzko S, Korponay-Szabo IR et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. Guidelines for the Diagnostik of Coeliac Disease. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition; 2012 DOI: 10.1097/MPG-0b013e31821a23d0
    Google Scholar
  • 13 Von Schenk U, Bender-Götze C, Koletzko B. Persistence of neurological damage induced by dietary vitamin B-12 deficiency in infancy. Archives of Disease in Childhood 1997; 77: 137-139
    CrossrefGoogle Scholar
  • 14 Korenke CG, Hunneman DH, Eber SW et al. Severe encephalopathy with epilepsy in an infant caused by subclinical maternal pernicious anemia. Case report and review of the literature. Eur J Pediatr 2004; 163: 196-201 (Review: Eur J Pediatr 2004; 163 (4 – 5): 207 – 209)
    CrossrefGoogle Scholar
  • 15 Burdach S. Schwerpunktthema Anämie. Monatsschrift Kinderheilkunde Heft 1/2015
    Google Scholar
  • 16 Finberg KE, Heeney MM, Champagna DR et al. Mutations in the TMPRSS6 cause iron refractory iron deficiency (IRIDA). Nat Genet 2008; 40: 569-571
    CrossrefGoogle Scholar
  • 17 Preza G, Ganz T, Nemeth E et al. Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload. J Clin Invest 2011; 121: 4880-4888
    CrossrefGoogle Scholar
  • 18 Malekzadeh MM, Radmard AR, Nouroozi A et al. Juvenile Hemochromatosis, Genetic Study and Long-term Follow up after Therapy. Middle East J Digest Disease 2014; 6: 87-92
    Google Scholar
  • 19 Cario H et al. Leitlinie: Cario H et al. Diagnostik und Therapie der sekundären Eisenüberladung bei Patienten mit angeborenen Anämien. http://www.awmf.org/uploads/tx_szleitlinien/025-029l.pdf
    Google Scholar
  • 20 Cappellini MD, Cohen A, Piga A et al. A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia. Blood 2006; 107: 3455-3462
    CrossrefGoogle Scholar
  • 21 Wonke B, Wright C, Hoffbrand AV. Combined therapy with deferiprone and desferrioxamine. Brit J Haematol 1998; 103: 361-364
    CrossrefGoogle Scholar