Int J Sports Med 2015; 36(07): 579-584
DOI: 10.1055/s-0034-1395588
Training & Testing
© Georg Thieme Verlag KG Stuttgart · New York

Effects of Swimming on the Inflammatory and Redox Response in a Model of Allergic Asthma

T. R. Brüggemann
1   Internal Medicine, School of Medicine of University of São Paulo, São Paulo, Brazil
L. C. M. Ávila
2   Physical Therapy, State University of Santa Catarina, Florianopolis, Brazil
B. Fortkamp
2   Physical Therapy, State University of Santa Catarina, Florianopolis, Brazil
F. R. Greiffo
3   Research, Nove de Julho University – UNINOVE, São Paulo, Brazil
F. Bobinski
4   Department of Biological Science, Federal University of Santa Catarina, Florianopolis, Brazil
L. Mazzardo-Martins
4   Department of Biological Science, Federal University of Santa Catarina, Florianopolis, Brazil
D. F. Martins
4   Department of Biological Science, Federal University of Santa Catarina, Florianopolis, Brazil
M. M. M. F. Duarte
5   Department of Health Science, Lutheran University of Brazil, Santa Maria, Brazil
A. Dafre
4   Department of Biological Science, Federal University of Santa Catarina, Florianopolis, Brazil
A. R. S. Santos
4   Department of Biological Science, Federal University of Santa Catarina, Florianopolis, Brazil
M. D. Silva
4   Department of Biological Science, Federal University of Santa Catarina, Florianopolis, Brazil
L. F. Souza
4   Department of Biological Science, Federal University of Santa Catarina, Florianopolis, Brazil
R. P. Vieira
6   Research, Nove de Julho University, São Paulo, Brazil
D. C. Hizume-Kunzler
2   Physical Therapy, State University of Santa Catarina, Florianopolis, Brazil
› Author Affiliations
Further Information

Publication History

accepted after revision 23 September 2014

Publication Date:
02 April 2015 (online)


In this study we hypothesized that swimming during sensitization phase could result in a preventive effect in mice with allergic asthma. Swiss mice were divided into 4 groups: Control and Swimming (non-sensitized), OVA and OVA+Swimming (sensitized). The allergic inflammation was induced by 2 intraperitoneal injections and 4 aerosol challenges using ovalbumin. Swimming sessions were performed at high intensity over 3 weeks. 48 h after the last challenge mice were euthanized. Swimming decreased OVA-increased total IgE, IL-1, IL-4, IL-5 and IL-6 levels, as well as the number of total cells, lymphocytes and eosinophils in bronchoalveolar lavage fluid, (p<0.05). Simultaneously, swimming also increased IL-10 and glutathione levels in the Swimming and OVA+Swimming groups (p<0.05). The levels of glutathione peroxidase and catalase were increased only in the Swimming group when compared to all groups (p<0.05). 21 days of swimming resulted in an attenuation of pulmonary allergic inflammation followed by an increase of glutathione levels in the OVA group. Swimming only increased the levels of glutathione peroxidase and catalase in non-sensitized mice (p<0.05). These data suggest that the pulmonary anti-inflammatory effects produced by 3 weeks of high-intensity swimming in this model of OVA-induced asthma may be, at least partly, modulated by reduced oxidative stress and increased IL-10 production.

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