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Semin Thromb Hemost 2015; 41(02): 178-187
DOI: 10.1055/s-0035-1544231
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Pros and Cons of Vitamin K Antagonists and Non–Vitamin K Antagonist Oral Anticoagulants

Nicoletta Riva
1   Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy
,
Walter Ageno
1   Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy
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Publikationsdatum:
19. Februar 2015 (online)

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Abstract

Anticoagulant treatment can be currently instituted with two different classes of drugs: the vitamin K antagonists (VKAs) and the newer, “novel” or non–vitamin K antagonist oral anticoagulant drugs (NOACs). The NOACs have several practical advantages over VKAs, such as the rapid onset/offset of action, the lower potential for food and drug interactions, and the predictable anticoagulant response. However, the VKAs currently have a broader spectrum of indications, a standardized monitoring test, and established reversal strategies. The NOACs emerged as alternative options for the prevention and treatment of venous thromboembolism and for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. Nevertheless, there remain some populations for whom the VKAs remain the most appropriate anticoagulant drug. This article discusses the advantages and disadvantages of VKAs and NOACs.

Keywords

vitamin K antagonist - direct thrombin inhibitor - direct factor Xa inhibitor
 

  • References

  • 1 Husted S, de Caterina R, Andreotti F , et al; ESC Working Group on Thrombosis Task Force on Anticoagulants in Heart Disease. Non-vitamin K antagonist oral anticoagulants (NOACs): No longer new or novel. Thromb Haemost 2014; 111 (5) 781-782
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 2 Whitlon DS, Sadowski JA, Suttie JW. Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition. Biochemistry 1978; 17 (8) 1371-1377
    CrossrefPubMedGoogle Scholar
  • 3 Ageno W, Gallus AS, Wittkowsky A, Crowther M, Hylek EM, Palareti G ; American College of Chest Physicians. Oral anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012; 141 (2, Suppl): e44S-e88S
    CrossrefPubMedGoogle Scholar
  • 4 Harenberg J. New anticoagulants in atrial fibrillation. Semin Thromb Hemost 2009; 35 (6) 574-585
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 5 Hankey GJ, Eikelboom JW. Dabigatran etexilate: a new oral thrombin inhibitor. Circulation 2011; 123 (13) 1436-1450
    CrossrefPubMedGoogle Scholar
  • 6 Wong PC, Pinto DJ, Zhang D. Preclinical discovery of apixaban, a direct and orally bioavailable factor Xa inhibitor. J Thromb Thrombolysis 2011; 31 (4) 478-492
    CrossrefPubMedGoogle Scholar
  • 7 Furugohri T, Isobe K, Honda Y , et al. DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles. J Thromb Haemost 2008; 6 (9) 1542-1549
    PubMedGoogle Scholar
  • 8 Perzborn E, Roehrig S, Straub A, Kubitza D, Mueck W, Laux V. Rivaroxaban: a new oral factor Xa inhibitor. Arterioscler Thromb Vasc Biol 2010; 30 (3) 376-381
    CrossrefPubMedGoogle Scholar
  • 9 Hirsh J. Oral anticoagulant drugs. N Engl J Med 1991; 324 (26) 1865-1875
    CrossrefPubMedGoogle Scholar
  • 10 Fung E, Patsopoulos NA, Belknap SM , et al. Effect of genetic variants, especially CYP2C9 and VKORC1, on the pharmacology of warfarin. Semin Thromb Hemost 2012; 38 (8) 893-904 [Erratum in: Semin Thromb Hemost. 2013;39(1):112]
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 11 Godbillon J, Richard J, Gerardin A, Meinertz T, Kasper W, Jähnchen E. Pharmacokinetics of the enantiomers of acenocoumarol in man. Br J Clin Pharmacol 1981; 12 (5) 621-629
    CrossrefPubMedGoogle Scholar
  • 12 Kubitza D, Becka M, Wensing G, Voith B, Zuehlsdorf M. Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939—an oral, direct Factor Xa inhibitor—after multiple dosing in healthy male subjects. Eur J Clin Pharmacol 2005; 61 (12) 873-880
    CrossrefPubMedGoogle Scholar
  • 13 Bounameaux H, Camm AJ. Edoxaban: an update on the new oral direct factor Xa inhibitor. Drugs 2014; 74 (11) 1209-1231
    CrossrefPubMedGoogle Scholar
  • 14 Reilly PA, Lehr T, Haertter S , et al; RE-LY Investigators. The effect of dabigatran plasma concentrations and patient characteristics on the frequency of ischemic stroke and major bleeding in atrial fibrillation patients: the RE-LY Trial (Randomized Evaluation of Long-Term Anticoagulation Therapy). J Am Coll Cardiol 2014; 63 (4) 321-328
    CrossrefPubMedGoogle Scholar
  • 15 Kubitza D, Roth A, Becka M , et al. Effect of hepatic impairment on the pharmacokinetics and pharmacodynamics of a single dose of rivaroxaban, an oral, direct Factor Xa inhibitor. Br J Clin Pharmacol 2013; 76 (1) 89-98
    CrossrefPubMedGoogle Scholar
  • 16 Heidbuchel H, Verhamme P, Alings M , et al; European Heart Rhythm Association. European Heart Rhythm Association Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation. Europace 2013; 15 (5) 625-651
    CrossrefPubMedGoogle Scholar
  • 17 Neumann I, Rada G, Claro JC , et al. Oral direct Factor Xa inhibitors versus low-molecular-weight heparin to prevent venous thromboembolism in patients undergoing total hip or knee replacement: a systematic review and meta-analysis. Ann Intern Med 2012; 156 (10) 710-719
    CrossrefPubMedGoogle Scholar
  • 18 Salazar CA, Malaga G, Malasquez G. Direct thrombin inhibitors versus vitamin K antagonists or low molecular weight heparins for prevention of venous thromboembolism following total hip or knee replacement. Cochrane Database Syst Rev 2010; (4) CD005981
    PubMedGoogle Scholar
  • 19 Albertsen IE, Larsen TB, Rasmussen LH, Overvad TF, Lip GY. Prevention of venous thromboembolism with new oral anticoagulants versus standard pharmacological treatment in acute medically ill patients: a systematic review and meta-analysis. Drugs 2012; 72 (13) 1755-1764
    CrossrefPubMedGoogle Scholar
  • 20 van der Hulle T, Kooiman J, den Exter PL, Dekkers OM, Klok FA, Huisman MV. Effectiveness and safety of novel oral anticoagulants as compared with vitamin K antagonists in the treatment of acute symptomatic venous thromboembolism: a systematic review and meta-analysis. J Thromb Haemost 2014; 12 (3) 320-328
    CrossrefPubMedGoogle Scholar
  • 21 Konstantinides SV, Torbicki A, Agnelli G , et al; Authors/Task Force Members; Authors/Task Force Members. 2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism: The Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC)Endorsed by the European Respiratory Society (ERS). Eur Heart J 2014; 35 (43) 3033-3073
    CrossrefPubMedGoogle Scholar
  • 22 Schulman S, Kearon C, Kakkar AK , et al; RE-MEDY Trial Investigators; RE-SONATE Trial Investigators. Extended use of dabigatran, warfarin, or placebo in venous thromboembolism. N Engl J Med 2013; 368 (8) 709-718
    CrossrefPubMedGoogle Scholar
  • 23 Bauersachs R, Berkowitz SD, Brenner B , et al; EINSTEIN Investigators. Oral rivaroxaban for symptomatic venous thromboembolism. N Engl J Med 2010; 363 (26) 2499-2510
    CrossrefPubMedGoogle Scholar
  • 24 Agnelli G, Buller HR, Cohen A , et al; PLIFY-EXT Investigators. Apixaban for extended treatment of venous thromboembolism. N Engl J Med 2013; 368 (8) 699-708
    CrossrefPubMedGoogle Scholar
  • 25 Ruff CT, Giugliano RP, Braunwald E , et al. Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials. Lancet 2014; 383 (9921) 955-962
    CrossrefPubMedGoogle Scholar
  • 26 Camm AJ, Lip GY, De Caterina R , et al; ESC Committee for Practice Guidelines (CPG). 2012 focused update of the ESC Guidelines for the management of atrial fibrillation: an update of the 2010 ESC Guidelines for the management of atrial fibrillation. Developed with the special contribution of the European Heart Rhythm Association. Eur Heart J 2012; 33 (21) 2719-2747
    CrossrefPubMedGoogle Scholar
  • 27 Cappato R, Ezekowitz MD, Klein AL , et al; on behalf of the X-VeRT Investigators. Rivaroxaban vs. vitamin K antagonists for cardioversion in atrial fibrillation. Eur Heart J 2014; 35 (47) 3346-3355
    CrossrefPubMedGoogle Scholar
  • 28 Providência R, Marijon E, Albenque JP , et al. Rivaroxaban and dabigatran in patients undergoing catheter ablation of atrial fibrillation. Europace 2014; 16 (8) 1137-1144
    CrossrefPubMedGoogle Scholar
  • 29 Eikelboom JW, Connolly SJ, Brueckmann M , et al; RE-ALIGN Investigators. Dabigatran versus warfarin in patients with mechanical heart valves. N Engl J Med 2013; 369 (13) 1206-1214
    CrossrefPubMedGoogle Scholar
  • 30 Oldgren J, Wallentin L, Alexander JH , et al. New oral anticoagulants in addition to single or dual antiplatelet therapy after an acute coronary syndrome: a systematic review and meta-analysis. Eur Heart J 2013; 34 (22) 1670-1680
    CrossrefPubMedGoogle Scholar
  • 31 Wiedermann CJ, Stockner I. Warfarin-induced bleeding complications - clinical presentation and therapeutic options. Thromb Res 2008; 122 (Suppl. 02) S13-S18
    CrossrefPubMedGoogle Scholar
  • 32 Linkins LA, Choi PT, Douketis JD. Clinical impact of bleeding in patients taking oral anticoagulant therapy for venous thromboembolism: a meta-analysis. Ann Intern Med 2003; 139 (11) 893-900
    CrossrefPubMedGoogle Scholar
  • 33 Sallah S, Thomas DP, Roberts HR. Warfarin and heparin-induced skin necrosis and the purple toe syndrome: infrequent complications of anticoagulant treatment. Thromb Haemost 1997; 78 (2) 785-790
    PubMedGoogle Scholar
  • 34 Giugliano RP, Ruff CT, Braunwald E , et al; ENGAGE AF-TIMI 48 Investigators. Edoxaban versus warfarin in patients with atrial fibrillation. N Engl J Med 2013; 369 (22) 2093-2104
    CrossrefPubMedGoogle Scholar
  • 35 Patel MR, Mahaffey KW, Garg J , et al; ROCKET AF Investigators. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med 2011; 365 (10) 883-891
    CrossrefPubMedGoogle Scholar
  • 36 Dentali F, Riva N, Crowther M, Turpie AG, Lip GY, Ageno W. Efficacy and safety of the novel oral anticoagulants in atrial fibrillation: a systematic review and meta-analysis of the literature. Circulation 2012; 126 (20) 2381-2391
    CrossrefPubMedGoogle Scholar
  • 37 Chatterjee S, Sardar P, Biondi-Zoccai G, Kumbhani DJ. New oral anticoagulants and the risk of intracranial hemorrhage: traditional and Bayesian meta-analysis and mixed treatment comparison of randomized trials of new oral anticoagulants in atrial fibrillation. JAMA Neurol 2013; 70 (12) 1486-1490
    PubMedGoogle Scholar
  • 38 Granger CB, Alexander JH, McMurray JJ , et al; ARISTOTLE Committees and Investigators. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med 2011; 365 (11) 981-992
    CrossrefPubMedGoogle Scholar
  • 39 Agnelli G, Buller HR, Cohen A , et al; AMPLIFY Investigators. Oral apixaban for the treatment of acute venous thromboembolism. N Engl J Med 2013; 369 (9) 799-808
    CrossrefPubMedGoogle Scholar
  • 40 Connolly SJ, Ezekowitz MD, Yusuf S , et al; RE-LY Steering Committee and Investigators. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009; 361 (12) 1139-1151 [Erratum in: N Engl J Med 2010; 363(19): 1877]
    CrossrefPubMedGoogle Scholar
  • 41 Schulman S, Kearon C, Kakkar AK , et al; RE-COVER Study Group. Dabigatran versus warfarin in the treatment of acute venous thromboembolism. N Engl J Med 2009; 361 (24) 2342-2352
    CrossrefPubMedGoogle Scholar
  • 42 Uchino K, Hernandez AV. Dabigatran association with higher risk of acute coronary events: meta-analysis of noninferiority randomized controlled trials. Arch Intern Med 2012; 172 (5) 397-402
    CrossrefPubMedGoogle Scholar
  • 43 Douxfils J, Buckinx F, Mullier F , et al. Dabigatran etexilate and risk of myocardial infarction, other cardiovascular events, major bleeding, and all-cause mortality: a systematic review and meta-analysis of randomized controlled trials. J Am Heart Assoc 2014; 3 (3) e000515
    CrossrefPubMedGoogle Scholar
  • 44 Lip GY, Lane DA. Does warfarin for stroke thromboprophylaxis protect against MI in atrial fibrillation patients?. Am J Med 2010; 123 (9) 785-789
    CrossrefPubMedGoogle Scholar
  • 45 Artang R, Rome E, Nielsen JD, Vidaillet HJ. Meta-analysis of randomized controlled trials on risk of myocardial infarction from the use of oral direct thrombin inhibitors. Am J Cardiol 2013; 112 (12) 1973-1979
    CrossrefPubMedGoogle Scholar
  • 46 Tripodi A. The laboratory and the new oral anticoagulants. Clin Chem 2013; 59 (2) 353-362
    CrossrefPubMedGoogle Scholar
  • 47 Mearns ES, White CM, Kohn CG , et al. Quality of vitamin K antagonist control and outcomes in atrial fibrillation patients: a meta-analysis and meta-regression. Thromb J 2014; 12: 14
    CrossrefPubMedGoogle Scholar
  • 48 Mearns ES, Kohn CG, Song JS , et al. Meta-analysis to assess the quality of international normalized ratio control and associated outcomes in venous thromboembolism patients. Thromb Res 2014; 134 (2) 310-319
    CrossrefPubMedGoogle Scholar
  • 49 Wan Y, Heneghan C, Perera R , et al. Anticoagulation control and prediction of adverse events in patients with atrial fibrillation: a systematic review. Circ Cardiovasc Qual Outcomes 2008; 1 (2) 84-91
    CrossrefPubMedGoogle Scholar
  • 50 Veeger NJ, Piersma-Wichers M, Tijssen JG, Hillege HL, van der Meer J. Individual time within target range in patients treated with vitamin K antagonists: main determinant of quality of anticoagulation and predictor of clinical outcome. A retrospective study of 2300 consecutive patients with venous thromboembolism. Br J Haematol 2005; 128 (4) 513-519
    CrossrefPubMedGoogle Scholar
  • 51 Baker WL, Cios DA, Sander SD, Coleman CI. Meta-analysis to assess the quality of warfarin control in atrial fibrillation patients in the United States. J Manag Care Pharm 2009; 15 (3) 244-252
    PubMedGoogle Scholar
  • 52 Garcia D, Barrett YC, Ramacciotti E, Weitz JI. Laboratory assessment of the anticoagulant effects of the next generation of oral anticoagulants. J Thromb Haemost 2013; 11 (2) 245-252
    CrossrefPubMedGoogle Scholar
  • 53 Lippi G, Favaloro EJ, Mattiuzzi C. Combined administration of antibiotics and direct oral anticoagulants: a renewed indication for laboratory monitoring?. Semin Thromb Hemost 2014; 40 (7) 756-765
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 54 van Ryn J, Stangier J, Haertter S , et al. Dabigatran etexilate—a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity. Thromb Haemost 2010; 103 (6) 1116-1127
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 55 Baglin T, Hillarp A, Tripodi A, Elalamy I, Buller H, Ageno W. Measuring Oral Direct Inhibitors (ODIs) of thrombin and factor Xa: a recommendation from the Subcommittee on Control of Anticoagulation of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis. J Thromb Haemost 2013; 11: 756-760
    CrossrefPubMedGoogle Scholar
  • 56 Di Minno A, Spadarella G, Prisco D, Franchini M, Lupoli R, Di Minno MN. Clinical judgment when using coagulation tests during direct oral anticoagulant treatment: a concise review. Semin Thromb Hemost 2013; 39 (7) 840-846
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 57 Harenberg J, Du S, Weiss C, Krämer R, Hoppensteadt D, Walenga J ; working party: methods to determine apixaban of the Subcommittee on Control of Anticoagulation of the International Society of Thrombosis and Haemostasis. Report of the Subcommittee on Control of Anticoagulation on the determination of the anticoagulant effects of apixaban: communication from the SSC of the ISTH. J Thromb Haemost 2014; 12 (5) 801-804
    CrossrefPubMedGoogle Scholar
  • 58 Harenberg J, Du S, Krämer S , et al. Novel methods for assessing oral direct factor Xa and thrombin inhibitors: use of point-of-care testing and urine samples. Semin Thromb Hemost 2013; 39 (1) 66-71
    PubMedGoogle Scholar
  • 59 Makris M, van Veen JJ, Maclean R. Warfarin anticoagulation reversal: management of the asymptomatic and bleeding patient. J Thromb Thrombolysis 2010; 29 (2) 171-181
    CrossrefPubMedGoogle Scholar
  • 60 Franchini M, Lippi G. Prothrombin complex concentrates: an update. Blood Transfus 2010; 8 (3) 149-154
    PubMedGoogle Scholar
  • 61 Dentali F, Marchesi C, Pierfranceschi MG , et al. Safety of prothrombin complex concentrates for rapid anticoagulation reversal of vitamin K antagonists. A meta-analysis. Thromb Haemost 2011; 106 (3) 429-438
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 62 Hickey M, Gatien M, Taljaard M, Aujnarain A, Giulivi A, Perry JJ. Outcomes of urgent warfarin reversal with frozen plasma versus prothrombin complex concentrate in the emergency department. Circulation 2013; 128 (4) 360-364
    CrossrefPubMedGoogle Scholar
  • 63 Hanger HC, Geddes JA, Wilkinson TJ, Lee M, Baker AE. Warfarin-related intracerebral haemorrhage: better outcomes when reversal includes prothrombin complex concentrates. Intern Med J 2013; 43 (3) 308-316
    CrossrefPubMedGoogle Scholar
  • 64 Woo CH, Patel N, Conell C , et al. Rapid Warfarin reversal in the setting of intracranial hemorrhage: a comparison of plasma, recombinant activated factor VII, and prothrombin complex concentrate. World Neurosurg 2014; 81 (1) 110-115
    CrossrefPubMedGoogle Scholar
  • 65 Majeed A, Meijer K, Larrazabal R , et al. Mortality in vitamin K antagonist-related intracerebral bleeding treated with plasma or 4-factor prothrombin complex concentrate. Thromb Haemost 2014; 111 (2) 233-239
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 66 Sarode R, Milling Jr TJ, Refaai MA , et al. Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: a randomized, plasma-controlled, phase IIIb study. Circulation 2013; 128 (11) 1234-1243
    CrossrefPubMedGoogle Scholar
  • 67 Holbrook A, Schulman S, Witt DM , et al; American College of Chest Physicians. Evidence-based management of anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012; 141 (2, Suppl): e152S-e184S
    CrossrefPubMedGoogle Scholar
  • 68 Voils SA, Baird B. Systematic review: 3-factor versus 4-factor prothrombin complex concentrate for warfarin reversal: does it matter?. Thromb Res 2012; 130 (6) 833-840
    CrossrefPubMedGoogle Scholar
  • 69 Rosovsky RP, Crowther MA. What is the evidence for the off-label use of recombinant factor VIIa (rFVIIa) in the acute reversal of warfarin? ASH evidence-based review 2008. Hematology (Am Soc Hematol Educ Program) 2008; 36-38
    PubMedGoogle Scholar
  • 70 Eerenberg ES, Kamphuisen PW, Sijpkens MK, Meijers JC, Buller HR, Levi M. Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. Circulation 2011; 124 (14) 1573-1579
    CrossrefPubMedGoogle Scholar
  • 71 Levi M, Moore KT, Castillejos CF , et al. Comparison of three-factor and four-factor prothrombin complex concentrates regarding reversal of the anticoagulant effects of rivaroxaban in healthy volunteers. J Thromb Haemost 2014; 12 (9) 1428-1436
    CrossrefPubMedGoogle Scholar
  • 72 Marlu R, Hodaj E, Paris A, Albaladejo P, Cracowski JL, Pernod G. Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: a randomised crossover ex vivo study in healthy volunteers. Thromb Haemost 2012; 108 (2) 217-224 [Erratum in: Thromb Haemost. 2013;109(1):169]
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 73 Siegal DM, Garcia DA, Crowther MA. How I treat target-specific oral anticoagulant-associated bleeding. Blood 2014; 123 (8) 1152-1158
    CrossrefPubMedGoogle Scholar
  • 74 Schiele F, van Ryn J, Canada K , et al. A specific antidote for dabigatran: functional and structural characterization. Blood 2013; 121 (18) 3554-3562
    CrossrefPubMedGoogle Scholar
  • 75 Crowther M, Kitt M, Lorenz T , et al. A phase 2 randomized, double-blind, placebo-controlled trial of PRT064445, a novel, universal antidote for direct and indirect factor Xa inhibitors. [abstract] J Thromb Haemost 2013; 11 (Suppl. 02) 30
    PubMedGoogle Scholar
  • 76 Crowther M, Mathur V, Kitt M , et al. A phase 2 randomized, double-blind, placebo-controlled trial demonstrating reversal of rivaroxaban-induced anticoagulation in healthy subjects by andexanet alfa (PRT064445), an antidote for FXa inhibitors. Blood 2013; 122: 3636 (abstract)
    PubMedGoogle Scholar
  • 77 Kaatz S, Crowther M. Reversal of target-specific oral anticoagulants. J Thromb Thrombolysis 2013; 36 (2) 195-202
    CrossrefPubMedGoogle Scholar
  • 78 Khadzhynov D, Wagner F, Formella S , et al. Effective elimination of dabigatran by haemodialysis. A phase I single-centre study in patients with end-stage renal disease. Thromb Haemost 2013; 109 (4) 596-605
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 79 Douketis JD, Spyropoulos AC, Spencer FA , et al. American College of Chest Physicians. Perioperative management of antithrombotic therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012; 141 (2, Suppl): e326S-e350S
    CrossrefPubMedGoogle Scholar
  • 80 Spyropoulos AC, Douketis JD. How I treat anticoagulated patients undergoing an elective procedure or surgery. Blood 2012; 120 (15) 2954-2962
    CrossrefPubMedGoogle Scholar
  • 81 Schulman S, Healey JS, Douketis JD, Delaney J, Morillo CA. Reduced-dose warfarin or interrupted warfarin with heparin bridging for pacemaker or defibrillator implantation: a randomized trial. Thromb Res 2014; 134 (4) 814-818
    CrossrefPubMedGoogle Scholar
  • 82 Birnie DH, Healey JS, Wells GA , et al; BRUISE CONTROL Investigators. Pacemaker or defibrillator surgery without interruption of anticoagulation. N Engl J Med 2013; 368 (22) 2084-2093
    CrossrefPubMedGoogle Scholar
  • 83 Horne R, Weinman J, Barber N, Elliot R, Morgan M. Concordance, adherence and compliance in medicine taking. Report for the National Coordinating Centre for NHS Service Delivery and Organization R & D (NCCSDO). Available at: http://www.nets.nihr.ac.uk/__data/assets/pdf_file/0009/64494/FR-08-1412-076.pdf . Accessed October 28, 2014
    PubMedGoogle Scholar
  • 84 Osterberg L, Blaschke T. Adherence to medication. N Engl J Med 2005; 353 (5) 487-497
    CrossrefPubMedGoogle Scholar
  • 85 Di Minno A, Spadarella G, Tufano A, Prisco D, Di Minno G. Ensuring medication adherence with direct oral anticoagulant drugs: lessons from adherence with vitamin K antagonists (VKAs). Thromb Res 2014; 133 (5) 699-704
    CrossrefPubMedGoogle Scholar
  • 86 Suryanarayan D, Schulman S. When the rubber meets the road: adherence and persistence with non-vitamin k antagonist oral anticoagulants and old oral anticoagulants in the real world-a problem or a myth?. Semin Thromb Hemost 2014; 40 (8) 852-859
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 87 Platt AB, Localio AR, Brensinger CM , et al. Risk factors for nonadherence to warfarin: results from the IN-RANGE study. Pharmacoepidemiol Drug Saf 2008; 17 (9) 853-860
    CrossrefPubMedGoogle Scholar
  • 88 Borg Xuereb C, Shaw RL, Lane DA. Patients' and health professionals' views and experiences of atrial fibrillation and oral-anticoagulant therapy: a qualitative meta-synthesis. Patient Educ Couns 2012; 88 (2) 330-337
    CrossrefPubMedGoogle Scholar
  • 89 Tang EO, Lai CS, Lee KK, Wong RS, Cheng G, Chan TY. Relationship between patients' warfarin knowledge and anticoagulation control. Ann Pharmacother 2003; 37 (1) 34-39
    CrossrefPubMedGoogle Scholar
  • 90 Clarkesmith DE, Pattison HM, Lip GY, Lane DA. Educational intervention improves anticoagulation control in atrial fibrillation patients: the TREAT randomised trial. PLoS ONE 2013; 8 (9) e74037
    CrossrefPubMedGoogle Scholar
  • 91 Ageno W, Crowther M, Baglin T, Falanga A, Buller H, Palareti G ; Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Selection and assessment of patients treated with the novel oral anticoagulant drugs: a recommendation from the Subcommittee on Control of Anticoagulation of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis. J Thromb Haemost 2013; 11 (1) 177-179
    CrossrefPubMedGoogle Scholar
  • 92 Laufs U, Rettig-Ewen V, Böhm M. Strategies to improve drug adherence. Eur Heart J 2011; 32 (3) 264-268
    CrossrefPubMedGoogle Scholar
  • 93 Schulman S, Shortt B, Robinson M, Eikelboom JW. Adherence to anticoagulant treatment with dabigatran in a real-world setting. J Thromb Haemost 2013; 11 (7) 1295-1299
    CrossrefPubMedGoogle Scholar
  • 94 Shore S, Carey EP, Turakhia MP , et al. Adherence to dabigatran therapy and longitudinal patient outcomes: insights from the Veterans health administration. Am Heart J 2014; 167 (6) 810-817
    CrossrefPubMedGoogle Scholar