Neuropediatrics 2015; 46(02): 110-115
DOI: 10.1055/s-0035-1546276
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Effectiveness and Tolerability of Perampanel in Children and Adolescents with Refractory Epilepsies: First Experiences

Anna Biró
1   Department of Pediatric Neurology and Neurological Rehabilitation, Schön Klinik Vogtareuth, Vogtareuth, Germany
,
Ulrich Stephani
2   Department of Neuropediatrics, Christian-Albrechts University, University Medical Center Schleswig-Holstein, Kiel, Germany
,
Tiziana Tarallo
2   Department of Neuropediatrics, Christian-Albrechts University, University Medical Center Schleswig-Holstein, Kiel, Germany
,
Thomas Bast
3   Epilepsy Center Kork, Kehl, Germany
,
Kurt Schlachter
4   Department of Pediatrics, Bregenz Regional Hospital, Bregenz, Austria
,
Martin Fleger
4   Department of Pediatrics, Bregenz Regional Hospital, Bregenz, Austria
,
Gerhard Kurlemann
5   Department of Neuropediatrics, University Children's Hospital Münster, Münster, Germany
,
Barbara Fiedler
5   Department of Neuropediatrics, University Children's Hospital Münster, Münster, Germany
,
Steffen Leiz
6   Department of Pediatrics, Dritter Orden Clinic, München, Germany
,
Marina Nikanorova
7   Children's Department, Danish Epilepsy Centre, Dianalund, Denmark
,
Markus Wolff
8   Department of Pediatric Neurology, University Children's Hospital Tübingen, Tübingen, Germany
,
Arnd Müller
1   Department of Pediatric Neurology and Neurological Rehabilitation, Schön Klinik Vogtareuth, Vogtareuth, Germany
,
Christina Selch
1   Department of Pediatric Neurology and Neurological Rehabilitation, Schön Klinik Vogtareuth, Vogtareuth, Germany
,
Martin Staudt
1   Department of Pediatric Neurology and Neurological Rehabilitation, Schön Klinik Vogtareuth, Vogtareuth, Germany
9   University Children's Hospital Tübingen, Tübingen, Germany
,
Gerhard Kluger
1   Department of Pediatric Neurology and Neurological Rehabilitation, Schön Klinik Vogtareuth, Vogtareuth, Germany
10   Paracelsus Medical University, Salzburg, Austria
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Weitere Informationen

Publikationsverlauf

05. September 2014

01. Januar 2015

Publikationsdatum:
02. März 2015 (online)

Abstract

Objective This article aims to report the first clinical experiences concerning effectiveness and tolerability of perampanel (PER) in a pediatric population with refractory epilepsies.

Patients and Methods This nonsponsored, observational, retrospective survey was conducted through collaboration with multiple centers in Europe. The clinical course of the first pediatric patients treated in these centers with PER was documented with the help of a questionnaire completed by the treating physicians. Effectiveness and adverse effects were evaluated. The study population consisted of 58 patients (mean age, 10.5 years; range, 2–17 years), suffering from various refractory epilepsies, classified as focal epilepsy (n = 36), unclassified generalized epilepsy (n = 12), Lennox–Gastaut syndrome (n = 5), West syndrome (n = 3), and Dravet syndrome (n = 2).

Results The response rate (≥ 50% seizure reduction) after the first 3 months of therapy was 31% (18/58 patients) in total. Complete seizure control was achieved in five patients (9% overall). Aggravation of seizures occurred in five cases (9%). The most frequently occurring adverse effects were reduced vigilance or fatigue (n = 16) and behavioral changes (n = 14).

Discussion PER seems to be effective also in children and adolescents with pharmaco-refractory epilepsies. Tolerability was acceptable.

Supplementary Material

 
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