Download PDF
Zeitschrift für Orthomolekulare Medizin 2016; 1(01): 10-16
DOI: 10.1055/s-0035-1547594
Wissen
Hippokrates Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG Stuttgart · New York

Stress als Promotor neuro­degenerativer Erkrankungen

Alfred Wolf
Further Information

Publication History

Publication Date:
20 April 2016 (online)

    Permissions and Reprints

Zusammenfassung

Chronischer psychosozialer und physischer Stress erhöht das Risiko für die Entwicklung einer Demenz, da er die Vulneration von neuronalen Netzwerken und Gliazellen verstärkt. Funktionelle Störungen bis hin zum Zelluntergang betreffen dabei auf der Grundlage verschiedener pathologischer Prozesse unterschiedliche Kompartimente und Zellsysteme.

Schlüsselwörter

Stress - neurodegenerative Erkrankungen - psychische Erkrankungen - Alzheimer - Morbus Parkinson - ALS - Cortisol - Brain-Derived Neurotrophic Factor - Nordrenalin - Glutamat
 

  • Literatur

  • 1 Ansorge MS, Hen R, Gingrich J. Neuro­developmental origins of depressive disorders. Curr Opinion Pharmacol 2007; 7: 8-17
    Google Scholar
  • 2 Arnsten AF, Pliszka SR. Catecholamine influences on prefrontal cortical function: Relevance to treatment of attention deficit/hyperactivity disorder and related disorders. Pharmacol Biochem Behav 2011; 99: 211-216
    CrossrefGoogle Scholar
  • 3 Bierhaus I, Humpert PM, Nawroth PP. Linking stress to inflammation. Anaesthesiol Clin 2006; 24: 325-340
    Google Scholar
  • 4 Caspi A et al. Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science 2003; 301: 386-389
    CrossrefGoogle Scholar
  • 5 Daskalakis NP et al. The three-hit concept of vulnerability and resilience: Toward understanding adaptation to early-life adversity outcome. Psychoneuroendocrinology 2013; 38: 1858-1873
    CrossrefGoogle Scholar
  • 6 Duman RS, Monteggio LM. A neurotrophic model for stress-related mood disorders. Biol Psychiatry 2006; 59: 1116-1127
    CrossrefGoogle Scholar
  • 7 Epel ES et al. Accelerated telomere shortening in response to life stress. PNAS 2004; 101: 17312-17317
    CrossrefGoogle Scholar
  • 8 Gandhi S, Abramow AY. Mechanism of ­oxidative stress in neurodegeneration. Oxid Med Cell Longev 2012; 428010 DOI: 10.1155/2012/428010.
    Google Scholar
  • 9 Gill JM, Saligan L, Woods S, Page G. PTSD is associated with an excess of inflammatory immune activities. Perspectives in Psychiatric Care 2009; 45: 262-277
    CrossrefGoogle Scholar
  • 10 Gola H et al. Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells. BMC Psychiatry 2013; 13: 40-48
    CrossrefPubMedGoogle Scholar
  • 11 Golier JA et al. Memory performance in Holocaust survivors with posttraumatic stress disorder. Am J Psychiatry 2002; 159: 1682-1688
    CrossrefGoogle Scholar
  • 12 Jellinger KA. Neurodegenerative Erkran­kungen (ZNS) – eine aktuelle Übersicht. J Neurol Neurochir Psychiatr 2005; 6: 9-18
    Google Scholar
  • 13 Joels M et al. Effects of chronic stress on structure and cell function in rat hippocampus and hypothalamus. Stress 2004; 7: 221-231
    CrossrefGoogle Scholar
  • 14 Johansson L et al. Midlife psychological stress and risk of dementia: a 35-year longitudinal population study. Brain 2010; 133: 2217-2224
    CrossrefGoogle Scholar
  • 15 Karabatsiakis A et al. Mitochondrial respiration in peripheral blood mononuclear cells correlates with depressive subsymptoms and severity of major depression. Translational Psychiatry 2014; 4: 1-7
    Google Scholar
  • 16 Kolassa IT, Elbert T. Structural and functional neuroplasticity in relation to traumatic stress. Curr Dir Psychol Science 2007; 16: 321-325
    Google Scholar
  • 17 Krugers HJ et al. Chronic stress effects on hippocampal structure and synaptic function: relevance for depression and normalization by antiglucocorticoid treatment. Front Synaptic Neuroscience 2010; 2: 1-10
    Google Scholar
  • 18 Magri F et al. Stress and dementia: the role of the hypothalamic-pituitary-adrenal axis. Aging Clin Exp Res 2005; 18: 167-170
    Google Scholar
  • 19 Pezawas L et al. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci 2005; 8: 828-834
    CrossrefGoogle Scholar
  • 20 Puyal J, Ginet V, Clarke PGH. Multiple interacting cell death mechanisms in the mediation of excitotoxicity and ischemic brain damage: A challenge for neuroprotection. Progress Neurobiol 2013; 105: 24-68
    CrossrefGoogle Scholar
  • 21 Sapolsky RM. Glucocorticoids, stress and their reverse neurological effects: relevance to aging. Exp Gerontol 1999; 34: 721-732
    CrossrefGoogle Scholar
  • 22 Swaab DF, Bao A, Lucassen PJ. The stress system in the human brain in depression and neurodegeneration. Ageing Res Rev 2005; 4: 141-194
    CrossrefGoogle Scholar
  • 23 Vanhooren V et al. Serum N-glycan profile shift during human aging. Experimental Gerontology 2010; 45: 738-743
    CrossrefGoogle Scholar
  • 24 von Zg, Bürkle A, Kirkwood TBL. Stress, DNA damage and ageing – an integrative approach. Experimental Gerontol 2001; 36: 1049-1062
    Google Scholar
  • 25 Weaver IC et al. Epigenetic programming by maternal behavior. Nat Neurosci 2004; 7: 847-854
    CrossrefGoogle Scholar
  • 26 Yaffe K et al. Posttraumatic stress disorder and risk of dementia among US veterans. Arch Gen Psychiatry 2010; 67: 608-613
    CrossrefGoogle Scholar