The Epidemiology of Posttraumatic Epilepsy

Abstract

Traumatic brain injury is an important contributor to morbidity and mortality, and results in reduced quality of life and lifespan: An estimated 1.7 million traumatic brain injuries occur annually in the United States alone. Traumatic brain injury carries an increased risk of epilepsy that correlates with the severity of the brain injury. Posttraumatic epilepsy accounts for less than 10% of epilepsy, but traumatic brain injury is one of only a few potentially preventable causes of epilepsy. Despite several well-controlled human studies, there is no current preventive treatment available for humans. Therefore, primary prevention is the only proven way to prevent posttraumatic epilepsy.

Keywords

traumatic brain injury - seizures - epilepsy - posttraumatic - epidemiology

• References

• 1 Pickelsimer EE, Selassie AW, Gu JK, Langlois JA. A population-based outcomes study of persons hospitalized with traumatic brain injury: operations of the South Carolina Traumatic Brain Injury Follow-up Registry. J Head Trauma Rehabil 2006; 21 (6) 491-504
• 2 Centers for Disease Control and Prevention. Traumatic Brain Injury in the United States: Emergency Department Visits, Hospitalizations, and Deaths, 2002–2006. Atlanta, GA: Centers for Disease Control and Prevention; 2012
• 3 Olesen J, Gustavsson A, Svensson M, Wittchen HU, Jönsson B ; CDBE2010 study group; European Brain Council. The economic cost of brain disorders in Europe. Eur J Neurol 2012; 19 (1) 155-162
• 4 Hesdorffer DC, Benn EK, Cascino GD, Hauser WA. Is a first acute symptomatic seizure epilepsy? Mortality and risk for recurrent seizure. Epilepsia 2009; 50 (5) 1102-1108
• 5 Lowenstein DH. Epilepsy after head injury: an overview. Epilepsia 2009; 50 (2) (Suppl. 02) 4-9
• 6 Beghi E, Carpio A, Forsgren L , et al. Recommendation for a definition of acute symptomatic seizure. Epilepsia 2010; 51 (4) 671-675
• 7 Thurman DJ, Beghi E, Begley CE , et al; ILAE Commission on Epidemiology. Standards for epidemiologic studies and surveillance of epilepsy. Epilepsia 2011; 52 (7) (Suppl. 07) 2-26
• 8 Annegers JF, Hauser WA, Coan SP, Rocca WA. A population-based study of seizures after traumatic brain injuries. N Engl J Med 1998; 338 (1) 20-24
• 9 Temkin NR, Dikmen SS, Wilensky AJ, Keihm J, Chabal S, Winn HR. A randomized, double-blind study of phenytoin for the prevention of post-traumatic seizures. N Engl J Med 1990; 323 (8) 497-502
• 10 Temkin NR. Risk factors for posttraumatic seizures in adults. Epilepsia 2003; 44 (10) (Suppl. 10) 18-20
• 11 Fisher RS, Acevedo C, Arzimanoglou A , et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia 2014; 55 (4) 475-482
• 12 Fisher RS, van Emde Boas W, Blume W , et al. Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia 2005; 46 (4) 470-472
• 13 Haltiner AM, Temkin NR, Dikmen SS. Risk of seizure recurrence after the first late posttraumatic seizure. Arch Phys Med Rehabil 1997; 78 (8) 835-840
• 14 Christensen J, Pedersen MG, Pedersen CB, Sidenius P, Olsen J, Vestergaard M. Long-term risk of epilepsy after traumatic brain injury in children and young adults: a population-based cohort study. Lancet 2009; 373 (9669) 1105-1110
• 15 Ferguson PL, Smith GM, Wannamaker BB, Thurman DJ, Pickelsimer EE, Selassie AW. A population-based study of risk of epilepsy after hospitalization for traumatic brain injury. Epilepsia 2010; 51 (5) 891-898
• 16 Emanuelson I, Uvebrant P. Occurrence of epilepsy during the first 10 years after traumatic brain injury acquired in childhood up to the age of 18 years in the south western Swedish population-based series. Brain Inj 2009; 23 (7) 612-616
• 17 McGuire SA, Marsh RW, Sowin TW, Robinson AY. Aeromedical decision making and seizure risk after traumatic brain injury: longitudinal outcome. Aviat Space Environ Med 2012; 83 (2) 140-143
• 18 Englander J, Bushnik T, Duong TT , et al. Analyzing risk factors for late posttraumatic seizures: a prospective, multicenter investigation. Arch Phys Med Rehabil 2003; 84 (3) 365-373
• 19 Zhao Y, Wu H, Wang X, Li J, Zhang S. Clinical epidemiology of posttraumatic epilepsy in a group of Chinese patients. Seizure 2012; 21 (5) 322-326
• 20 Angeleri F, Majkowski J, Cacchiò G , et al. Posttraumatic epilepsy risk factors: one-year prospective study after head injury. Epilepsia 1999; 40 (9) 1222-1230
• 21 Wang H, Xin T, Sun X , et al. Post-traumatic seizures—a prospective, multicenter, large case study after head injury in China. Epilepsy Res 2013; 107 (3) 272-278
• 22 Jennett WB, Lewin W. Traumatic epilepsy after closed head injuries. J Neurol Neurosurg Psychiatry 1960; 23: 295-301
• 23 Asikainen I, Kaste M, Sarna S. Early and late posttraumatic seizures in traumatic brain injury rehabilitation patients: brain injury factors causing late seizures and influence of seizures on long-term outcome. Epilepsia 1999; 40 (5) 584-589
• 24 Raymont V, Salazar AM, Lipsky R, Goldman D, Tasick G, Grafman J. Correlates of posttraumatic epilepsy 35 years following combat brain injury. Neurology 2010; 75 (3) 224-229
• 25 Hakimian S, Kershenovich A, Miller JW , et al. Long-term outcome of extratemporal resection in posttraumatic epilepsy. Neurosurg Focus 2012; 32 (3) E10
• 26 Christensen J. Traumatic brain injury: risks of epilepsy and implications for medicolegal assessment. Epilepsia 2012; 53 (4) (Suppl. 04) 43-47
• 27 Schmidt D, Friedman D, Dichter MA. Anti-epileptogenic clinical trial designs in epilepsy: issues and options. Neurotherapeutics 2014; 11 (2) 401-411
• 28 Temkin NR. Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials. Epilepsia 2001; 42 (4) 515-524
• 29 Temkin NR. Preventing and treating posttraumatic seizures: the human experience. Epilepsia 2009; 50 (2) (Suppl. 02) 10-13
• 30 Glötzner FL, Haubitz I, Miltner F, Kapp G, Pflughaupt KW. [Seizure prevention using carbamazepine following severe brain injuries]. Neurochirurgia (Stuttg) 1983; 26 (3) 66-79
• 31 Temkin NR, Anderson GD, Winn HR , et al. Magnesium sulfate for neuroprotection after traumatic brain injury: a randomised controlled trial. Lancet Neurol 2007; 6 (1) 29-38
• 32 Chen LL, Baca CB, Choe J, Chen JW, Ayad ME, Cheng EM. Posttraumatic epilepsy in Operation Enduring Freedom/Operation Iraqi Freedom veterans. Mil Med 2014; 179 (5) 492-496