Semin Neurol 2015; 35(04): 424-430
DOI: 10.1055/s-0035-1558972
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Diabetic Neuropathies

Aaron Izenberg
1   Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Bruce A. Perkins
2   Division of Endocrinology and Metabolism, Department of Medicine, University of Toronto and Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
Vera Bril
3   Division of Neurology, Department of Medicine, Toronto General Hospital, Toronto, Ontario, Canada
› Author Affiliations
Further Information

Publication History

Publication Date:
06 October 2015 (online)


Diabetes mellitus is a common condition and diabetics are prone to develop a spectrum of neuropathic complications ranging from symmetric and diffuse to asymmetric and focal neuropathies that may be associated with significant morbidity. Diabetic sensorimotor polyneuropathy is the most common of these complications, occurring in patients with type 1 and 2 diabetes mellitus, as well as in those with prediabetes and glucose intolerance. In this review, the authors discuss the wide variety of neuropathies that can present in the context of diabetes, including the clinical manifestations, diagnostic features, and approach to management.