Semin Neurol 2015; 35(04): 398-406
DOI: 10.1055/s-0035-1558974
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Acquired Immunologic Neuropathies

Jeffrey A. Allen
1   Department of Neurology, University of Minnesota, Minneapolis, Minnesota
2   Department of Neurology, Northwestern University, Chicago, Illinois
,
Gareth J. Parry
1   Department of Neurology, University of Minnesota, Minneapolis, Minnesota
› Author Affiliations
Further Information

Publication History

Publication Date:
06 October 2015 (online)

Abstract

The acquired immunologic neuropathies are a collection of neuropathic conditions that result from abnormal immune responses that target peripheral nerve myelin, Schwann cells, or axons. Although the clinical features and diagnostic data are sometimes overlapping, the specific disorders are heterogeneous in pathogenesis, treatment, and prognosis. Importantly, there is no consensus as to which neuropathies are distinct conditions and which are better considered as variants or subtypes. The authors discuss the clinical, electrophysiological, histopathological, and treatment features that define the acquired immunomediated neuropathies, calling attention to differences that are observed between the specific neuropathies as well as the differences in the presumed variants within each syndrome.