Semin Neurol 2015; 35(04): 347-359
DOI: 10.1055/s-0035-1558980
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Clinical Evaluation and Management of Inflammatory Myopathies

Sameer Chhibber
1   Division of Neurology, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
Anthony A. Amato
2   Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
› Author Affiliations
Further Information

Publication History

Publication Date:
06 October 2015 (online)


The idiopathic inflammatory myopathies are classified into four distinct subtypes: dermatomyositis, polymyositis, inclusion body myositis, and immunomediated necrotizing myopathy. These subtypes are clinically, histologically, and pathogenically distinct. Dermatomyositis, polymyositis, and necrotizing myopathy generally respond to immunotherapy, whereas inclusion body myositis does not. In this review, the authors focus on the clinical evaluation and management of idiopathic inflammatory myopathies and highlight recent therapeutic studies and the evolving role of myositis-specific antibodies.