Semin Neurol 2015; 35(05): 557-563
DOI: 10.1055/s-0035-1563580
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Functional Vision Disorder

Robert A. Egan
1   Oregon Neurology, Portland, Oregon
,
W. Curt LaFrance Jr.
2   Rhode Island Hospital, Brown University, Providence, Rhode Island
› Author Affiliations
Further Information

Publication History

Publication Date:
06 October 2015 (online)

Abstract

Functional vision disorder (FVD) is a common problem seen in many neurologic and ophthalmologic practitioners' offices and may occur in isolation or in the presence of medical illness. This disorder presents with visual or oculomotor symptoms and manifests as vision loss in one or both eyes, visual field loss, double vision, oscillopsia, anisocoria, blepharospasm, or ptosis. Manual perimetry is the most effective method for determining functional visual loss, and the presence of a central scotoma in a functional visual field signifies that a neuropathophysiologic process is almost certainly present. The exact neuropathophysiologic mechanism of this disorder is unknown; however, information can be drawn from the small studies of FVD samples and studies examining neuropsychiatric factors in other conversion disorder semiologies. Psychological and psychiatric interventions can be useful in treating these patients.

 
  • References

  • 1 American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Arlington, VA: American Psychiatry Publishing; 2013
  • 2 Bose S, Kupersmith MJ. Neuro-ophthalmologic presentations of functional visual disorders. Neurol Clin 1995; 13 (2) 321-339
  • 3 Scott JA, Egan RA. Prevalence of organic neuro-ophthalmologic disease in patients with functional visual loss. Am J Ophthalmol 2003; 135 (5) 670-675
  • 4 Keltner JL, May WN, Johnson CA, Post RB. The California syndrome. Functional visual complaints with potential economic impact. Ophthalmology 1985; 92 (3) 427-435
  • 5 Rada RT, Krill AE, Meyer GG, Armstrong D. Visual conversion reaction in children. II. Follow-up. Psychosomatics 1973; 14 (5) 271-276
  • 6 Sletteberg O, Bertelsen T, Høvding G. The prognosis of patients with hysterical visual impairment. Acta Ophthalmol (Copenh) 1989; 67 (2) 159-163
  • 7 Egan RA, Butler RW. Neuropsychological profiles of patients with functional vision loss. Paper presented at: 32nd Annual North American Neuro-Ophthalmology Society Meeting; February 25–March 2, 2006; Tucson, AZ
  • 8 Bruce BB, Newman NJ. Functional visual loss. Neurol Clin 2010; 28 (3) 789-802
  • 9 Kinori M, Wygnanski-Jaffe T, Huna-Baron R. Functional visual loss in an Israeli pediatric population. Isr Med Assoc J 2011; 13 (11) 684-688
  • 10 Stone J, LaFrance Jr WC, Levenson JL, Sharpe M. Issues for DSM-5: Conversion disorder. Am J Psychiatry 2010; 167 (6) 626-627
  • 11 Stone J, LaFrance Jr WC, Brown R, Spiegel D, Levenson JL, Sharpe M. Conversion disorder: current problems and potential solutions for DSM-5. J Psychosom Res 2011; 71 (6) 369-376
  • 12 Golnik KC, Lee AG, Eggenberger ER. The monocular vertical prism dissociation test. Am J Ophthalmol 2004; 137 (1) 135-137
  • 13 Slavin ML. The prism dissociation test in detecting unilateral functional visual loss. J Clin Neuroophthalmol 1990; 10 (2) 127-130
  • 14 Levy NS, Glick EB. Stereoscopic perception and Snellen visual acuity. Am J Ophthalmol 1974; 78 (4) 722-724
  • 15 Rajan MS, Bremner FD, Riordan-Eva P. Pupil perimetry in the diagnosis of functional visual field loss. J R Soc Med 2002; 95 (10) 498-500
  • 16 Bourke RD, Gole GA. Detection of functional vision loss using the Ishihara plates. Aust N Z J Ophthalmol 1994; 22 (2) 115-118
  • 17 Shults WT, Stark L, Hoyt WF, Ochs AL. Normal saccadic structure of voluntary nystagmus. Arch Ophthalmol 1977; 95 (8) 1399-1404
  • 18 Gundogan FC, Sobaci G, Bayer A. Pattern visual evoked potentials in the assessment of visual acuity in malingering. Ophthalmology 2007; 114 (12) 2332-2337
  • 19 Schoenfeld MA, Hassa T, Hopf JM, Eulitz C, Schmidt R. Neural correlates of hysterical blindness. Cereb Cortex 2011; 21 (10) 2394-2398
  • 20 Werring DJ, Weston L, Bullmore ET, Plant GT, Ron MA. Functional magnetic resonance imaging of the cerebral response to visual stimulation in medically unexplained visual loss. Psychol Med 2004; 34 (4) 583-589
  • 21 Ney JJ, Volpe NJ, Liu GT, Balcer LJ, Moster ML, Galetta SL. Functional visual loss in idiopathic intracranial hypertension. Ophthalmology 2009; 116 (9) 1808-1813.e1
  • 22 Egan RA, Scott JA. Functional vision loss in neuro-ophthalmic disease. Paper presented at: 31st Annual North American Neuro-Ophthalmology Society Meeting; February 12–17, 2005; Copper Mountain, CO
  • 23 Shindler KS, Galetta SL, Volpe NJ. Functional visual loss. Curr Treat Options Neurol 2004; 6 (1) 67-73
  • 24 Kathol RG, Cox TA, Corbett JJ, Thompson HS. Functional visual loss. Follow-up of 42 cases. Arch Ophthalmol 1983; 101 (5) 729-735
  • 25 Thompson HS. Functional visual loss. Am J Ophthalmol 1985; 100 (1) 209-213
  • 26 Reiter J, Andrews D, Reiter C, LaFrance Jr WC. Taking Control of Your Seizures: Workbook. New York, NY: Oxford University Press; 2015
  • 27 LaFrance Jr WC, Wincze JP. Treating Nonepileptic Seizures: Therapist Guide. New York, NY: Oxford University Press; 2015
  • 28 LaFrance Jr WC, Baird GL, Barry JJ , et al; NES Treatment Trial (NEST-T) Consortium. Multicenter pilot treatment trial for psychogenic nonepileptic seizures: a randomized clinical trial. JAMA Psychiatry 2014; 71 (9) 997-1005
  • 29 Egan RA. Treatment of functional vision loss with duloxetine. Paper presented at: 38th Annual North American Neuro-Ophthalmology Society Meeting; February 11–16, 2012; San Antonio, TX