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Neuropediatrics 2016; 47(01): 012-019
DOI: 10.1055/s-0035-1567873
Review Article
Georg Thieme Verlag KG Stuttgart · New York

Neonatal Seizures: A Review of Outcomes and Outcome Predictors

Francesco Pisani
1   Child Neuropsychiatry Unit, Neuroscience Department, University of Parma, Parma, Italy
,
Carlotta Spagnoli
1   Child Neuropsychiatry Unit, Neuroscience Department, University of Parma, Parma, Italy
› Author Affiliations
Further Information

Publication History

08 June 2015

21 September 2015

Publication Date:
20 November 2015 (online)

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Abstract

The majority of neonatal seizures are of acute symptomatic origin, and their occurrence is associated with higher mortality and morbidity compared with the general population, even if there is conflicting evidence of a detrimental effect per se. Etiology is considered the main determinant of outcome, but other factors, including gestational age, brain damage severity, neonatal neurological examination, and electroencephalographically (EEG) interictal and ictal characteristics are also related to neurodevelopmental outcome or death. Therefore, accuracy in early prognostication since the neonatal period can be improved by conveniently integrating different clinical and instrumental findings.

The aim of this review is first to review the outcome of newborns with seizures (mortality, epilepsy, cerebral palsy, and intellectual disability), second to review the risk factors for adverse outcome after seizures in the newborn period, considering clinical, EEG/amplitude-integrated EEG, and neuroimaging findings associated with adverse outcome and lack of response to treatment, and finally to review published scoring systems for predicting neurologic outcome after neonatal seizures.

Keywords

neonatal seizures - outcome - scoring system - risk factors - prognostication

Note

The topic of this review has been presented at the “Progress in epileptic disorders workshop. Seizures of onset in the first two years of life,” Rome November 14 to 17, 2013, in a conference as well as a manuscript format. The latter is due to be published as a corresponding book chapter, in a more extended and complete form than in this review.


 

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