Thorac Cardiovasc Surg Rep 2016; 05(01): 16-17
DOI: 10.1055/s-0035-1569993
Case Report: Thoracic
Georg Thieme Verlag KG Stuttgart · New York

Lung Transplantation in a Multidrug-Resistant Gram-Negative Acinetobacter Baumannii–Colonized Patient: A Case Report

Katharina Huenges
1   Department of Cardiovascular Surgery, University of Schleswig-Holstein Campus Kiel, Kiel, Germany
,
Alexander Reinecke
1   Department of Cardiovascular Surgery, University of Schleswig-Holstein Campus Kiel, Kiel, Germany
,
Burkhard Bewig
2   Department of Internal Medicine I, University of Schleswig Holstein Campus Kiel, Kiel, Germany
,
Assad Haneya
1   Department of Cardiovascular Surgery, University of Schleswig-Holstein Campus Kiel, Kiel, Germany
,
Jochen Cremer
1   Department of Cardiovascular Surgery, University of Schleswig-Holstein Campus Kiel, Kiel, Germany
› Author Affiliations
Further Information

Publication History

26 July 2015

19 October 2015

Publication Date:
16 December 2015 (online)

Abstract

Colonization or infection with various pathogens is frequently found in patients listed for lung transplantation. We describe a case of a 50-year-old woman with α-1-antitrypsin deficiency, which was listed for double-lung transplantation, with multidrug-resistant gram-negative Acinetobacter baumannii (MRGN4-Ab) skin colonization. Transplantation was successfully performed. Colistin (Polymyxine E) was administered intravenously and through inhalation in the first month. MRGN4-Ab was still detectable in skin swabs without evidence of infection. After good recovery and clinical inapparence, the patient was discharged 2 months after transplantation.

 
  • References

  • 1 Fournier PE, Richet H. The epidemiology and control of Acinetobacter baumannii in health care facilities. Clin Infect Dis 2006; 42 (5) 692-699
  • 2 Magiorakos AP, Srinivasan A, Carey RB , et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect 2012; 18 (3) 268-281
  • 3 Martins N, Martins IS, de Freitas WV , et al. Severe infection in a lung transplant recipient caused by donor-transmitted carbapenem-resistant Acinetobacter baumannii. Transpl Infect Dis 2012; 14 (3) 316-320
  • 4 Andini R, Agrusta F, Mattucci I , et al. Recipient-born bloodstream infection due to extensively drug-resistant Acinetobacter baumannii after emergency heart transplant: report of a case and review of the literature. Infection 2015; 43 (5) 609-613
  • 5 Kim SB, Min YH, Cheong JW , et al. Incidence and risk factors for carbapenem- and multidrug-resistant Acinetobacter baumannii bacteremia in hematopoietic stem cell transplantation recipients. Scand J Infect Dis 2014; 46 (2) 81-88
  • 6 Kitazono H, Rog D, Grim SA, Clark NM, Reid GE. Acinetobacter baumannii infection in solid organ transplant recipients. Clin Transplant 2015; 29 (3) 227-232
  • 7 Nunley DR, Bauldoff GS, Mangino JE, Pope-Harman AL. Mortality associated with Acinetobacter baumannii infections experienced by lung transplant recipients. Lung 2010; 188 (5) 381-385
  • 8 de Gouvêa EF, Martins IS, Halpern M , et al. The influence of carbapenem resistance on mortality in solid organ transplant recipients with Acinetobacter baumannii infection. BMC Infect Dis 2012; 12: 351
  • 9 Shields RK, Clancy CJ, Gillis LM , et al. Epidemiology, clinical characteristics and outcomes of extensively drug-resistant Acinetobacter baumannii infections among solid organ transplant recipients. PLoS ONE 2012; 7 (12) e52349