Role of Leukocyte–Platelet-Rich Fibrin in Endoscopic Endonasal Skull Base Surgery Defect Reconstruction

Liuba Soldatova; Raewyn G. Campbell; Ahmad H. Elkhatib; Thomas W. Schmidt; Nelson R. Pinto; Jaime M. Pinto; Daniel M. Prevedello; Leo F. Ditzel Filho; Bradley A. Otto; Ricardo L. Carrau

doi:10.1055/s-0036-1584894

Journal of Neurological Surgery Part B: Skull Base, Inhaltsverzeichnis

J Neurol Surg B Skull Base 2017; 78(01): 059-062
DOI: 10.1055/s-0036-1584894

Original Article

Georg Thieme Verlag KG Stuttgart · New York

Role of Leukocyte–Platelet-Rich Fibrin in Endoscopic Endonasal Skull Base Surgery Defect Reconstruction

Liuba Soldatova

¹Department of Otolaryngology - Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States

,

Raewyn G. Campbell

¹Department of Otolaryngology - Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States

,

Ahmad H. Elkhatib

¹Department of Otolaryngology - Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States

,

Thomas W. Schmidt

²Department of Otolaryngology - Head & Neck Surgery, Universidad de Concepción, Concepcion, Chile

,

Nelson R. Pinto

³Graduate School of Periodontics and Implant Dentistry, Research Center for Regenerative Medicine and Tissue Engineering, University of the Andes-Chile, Concepcion, Chile

,

Jaime M. Pinto

⁴Department of Neurosurgery, Universidad de Concepción, Concepcion, Chile

,

Daniel M. Prevedello

¹Department of Otolaryngology - Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States

⁵Department of Neurologic Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States

,

Leo F. Ditzel Filho

¹Department of Otolaryngology - Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States

,

Bradley A. Otto

¹Department of Otolaryngology - Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States

⁵Department of Neurologic Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States

,

Ricardo L. Carrau

¹Department of Otolaryngology - Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States

⁵Department of Neurologic Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States

› Institutsangaben

Abstract

Objective Advancements in endoscopic endonasal approaches have increased the extent and complexity of skull base resections, in turn demanding the development of novel techniques for skull base defect reconstruction. The objective of this pilot study was to investigate the effect of leukocyte–platelet-rich fibrin (L-PRF) on the postoperative healing after endoscopic skull base surgery.

Methods Between January and May of 2015, 47 patients underwent endoscopic endonasal resection of sellar, parasellar, and suprasellar lesions with the application of L-PRF membranes during the skull base reconstruction at two surgical centers. Early postoperative records were retrospectively reviewed.

Results We found that 21 days following the surgery, 17/41 patients (42%) demonstrated improvement in the crusting score as compared with their 7 day postoperative examination. Ten of these patients (23%) showed no crusting. Fourteen (34%) patients had no change in the crusting score. Six patient records were incomplete. A total of 4/47 cases (8.5%) had postoperative cerebrospinal fluid leak requiring surgical repair.

Conclusion This study demonstrates the potential utility of L-PRF membranes for skull base defect reconstruction. Future studies will be conducted to better assess the role of L-PRF in endoscopic skull base surgery.

Keywords

leukocyte–platelet-rich fibrin - endoscopic endonasal approach - endoscopic skull base surgery - skull base defect reconstruction

Volltext

Referenzen

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