Semin Neurol 2016; 36(05): 449-455
DOI: 10.1055/s-0036-1586264
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Sleepiness

Jeffrey M. Ellenbogen
1   Department of Neurology and Sleep Medicine, Johns Hopkins University, Baltimore, Maryland
› Author Affiliations
Further Information

Publication History

Publication Date:
23 September 2016 (online)

Abstract

Sleep medicine can be a particularly rewarding clinical area for neurologists. After all, the driving organ of sleep is the brain. Many of the sleep disorders are primary brain disorders, whereas other sleep disorders (and their medications) influence brain function. But without an organized approach, even the engaged and motivated neurologist can easily become frustrated when dealing with patients whose concerns center on an undesirable degree of sleepiness. Lost in the thicket of information provided during the patient–doctor encounter, many physicians are unable to direct the history toward particular diagnostic hypotheses. So, rather than provide an exhaustive and disorganized set of details about sleep medicine, the author instead shares pearls of sleep medicine in the context of an overall framework, with the goal to foster targeted history-taking for the successful diagnosis of a patient struggling with maintaining wakefulness. The topic of excessive sleepiness will be covered because it is so common and because its mastery is fundamental to approaching most patients with sleep disorders. Common and important pitfalls regarding the topic of sleepiness—and how to avoid them—will be discussed. Misdiagnoses and mismanagement are easy to avoid if this entire framework is kept in mind.

 
  • References

  • 1 Young TB. Epidemiology of daytime sleepiness: definitions, symptomatology, and prevalence. J Clin Psychiatry 2004; 65 (Suppl. 16) 12-16
  • 2 NCSDR/NHTSA Expert Panel on Driver Fatigue and Sleepiness. Drowsy Driving and Automobile Crashes. Available at: http://www.nhtsa.gov/people/injury/drowsy_driving1/drowsy.html . Accessed July 6, 2016
  • 3 Borbély AA, Achermann P. Sleep homeostasis and models of sleep regulation. J Biol Rhythms 1999; 14 (6) 557-568
  • 4 Wyatt JK, Ritz-De Cecco A, Czeisler CA, Dijk DJ. Circadian temperature and melatonin rhythms, sleep, and neurobehavioral function in humans living on a 20-h day. Am J Physiol 1999; 277 (4 Pt 2) R1152-R1163
  • 5 Czeisler CA, Duffy JF, Shanahan TL , et al. Stability, precision, and near-24-hour period of the human circadian pacemaker. Science 1999; 284 (5423) 2177-2181
  • 6 Wyatt JK. Delayed sleep phase syndrome: pathophysiology and treatment options. Sleep 2004; 27 (6) 1195-1203
  • 7 Saper CB, Fuller PM, Pedersen NP, Lu J, Scammell TE. Sleep state switching. Neuron 2010; 68 (6) 1023-1042
  • 8 American Academy of Sleep Medicine. The International Classification of Sleep Disorders, Third Edition (ICSD-3). Darien, IL: American Academy of Sleep Medicine; 2014
  • 9 Chervin RD. Sleepiness, fatigue, tiredness, and lack of energy in obstructive sleep apnea. Chest 2000; 118 (2) 372-379
  • 10 Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 1991; 14 (6) 540-545
  • 11 Chervin RD. The multiple sleep latency test and Epworth sleepiness scale in the assessment of daytime sleepiness. J Sleep Res 2000; 9 (4) 399-401
  • 12 Evenson KR, Goto MM, Furberg RD. Systematic review of the validity and reliability of consumer-wearable activity trackers. Int J Behav Nutr Phys Act 2015; 12: 159
  • 13 Yalamanchali S, Farajian V, Hamilton C, Pott TR, Samuelson CG, Friedman M. Diagnosis of obstructive sleep apnea by peripheral arterial tonometry: meta-analysis. JAMA Otolaryngol Head Neck Surg 2013; 139 (12) 1343-1350
  • 14 Van Dongen HPA, Maislin G, Mullington JM, Dinges DF. The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation. Sleep 2003; 26 (2) 117-126
  • 15 Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med 2005; 353 (19) 2034-2041
  • 16 Van Cauter E, Sturis J, Byrne MM , et al. Demonstration of rapid light-induced advances and delays of the human circadian clock using hormonal phase markers. Am J Physiol 1994; 266 (6 Pt 1) E953-E963
  • 17 Mignot E. Genetics of narcolepsy and other sleep disorders. Am J Hum Genet 1997; 60 (6) 1289-1302
  • 18 Scammell TE. The neurobiology, diagnosis, and treatment of narcolepsy. Ann Neurol 2003; 53 (2) 154-166