Pregnancy outcomes after previable preterm premature rupture of membranes

Objective: A current assessment of the gestational outcomes in pregnancies complicated by previable preterm premature rupture of membranes (previable PPROM) (< 24 weeks of gestation) and neonatal survival after expectant treatment.

Study design: The perinatal data was collected for the last five years regarding patients with previable PPROM, including the short-term neonatal outcomes.

Results: 63 patients with 83 fetuses (46 singletons and 37 multiples) were hospitalized. A total of 37.5% (n = 24) patients opted for termination of pregnancy (TOP), 19% (n = 12) suffered a miscarriage, while 42.8% (n = 27) proceeded to a live birth; including 18 singletons and 21 neonates from multiple pregnancies after an average latency period of 39 days (range 2 – 126 days). Of the life born infants 81.6% survived the perinatal period. The most common neonatal sequelae were infant respiratory distress syndrome, bronchopulmonary dysplasia, and connatal infection. The overall survival, not including elective termination but including miscarriages, was 56.3%.