Thorac Cardiovasc Surg 2017; 65(01): 009-017
DOI: 10.1055/s-0036-1588007
Original Cardiovascular
Georg Thieme Verlag KG Stuttgart · New York

Total Anomalous Pulmonary Venous Connection: A 40 years' Experience Analysis

Anaïs Lemaire
1  Department of Cardiac Surgery, Hopital Europeen Georges Pompidou, Paris, Île-de-France, France
2  Department of Pediatric Cardiac Surgery, Hopital Cardio-vasculaire et Pneumologique Louis Pradel, Lyon, Rhône-Alpes, France
,
Sylvie DiFilippo
2  Department of Pediatric Cardiac Surgery, Hopital Cardio-vasculaire et Pneumologique Louis Pradel, Lyon, Rhône-Alpes, France
,
Jean-Jacques Parienti
3  Department of Research and Biostatistic, Centre Hospitalier Universitaire de Caen, Caen, Basse-Normandie, France
,
Olivier Metton
2  Department of Pediatric Cardiac Surgery, Hopital Cardio-vasculaire et Pneumologique Louis Pradel, Lyon, Rhône-Alpes, France
,
Julia Mitchell
2  Department of Pediatric Cardiac Surgery, Hopital Cardio-vasculaire et Pneumologique Louis Pradel, Lyon, Rhône-Alpes, France
,
Roland Hénaine
2  Department of Pediatric Cardiac Surgery, Hopital Cardio-vasculaire et Pneumologique Louis Pradel, Lyon, Rhône-Alpes, France
,
Jean Ninet
2  Department of Pediatric Cardiac Surgery, Hopital Cardio-vasculaire et Pneumologique Louis Pradel, Lyon, Rhône-Alpes, France
› Author Affiliations
Further Information

Publication History

23 May 2016

15 July 2016

Publication Date:
16 September 2016 (online)

Abstract

Background Total anomalous pulmonary venous connection is a rare cardiac malformation associated with significant morbidity and mortality rates. We report a large surgical series study to evaluate mid-term and long-term results of conventional surgical techniques.

Methods and Results We performed a retrospective analytic study of all patients operated on for simple total anomalous pulmonary venous connection in the University Hospital of Lyon, France, between January 1973 and June 2014. A total of 180 patients were included (43% supracardiac, 27% intracardiac, 19% infracardiac, and 11% mixed types). Mean cardiopulmonary bypass and aortic cross clamp times were respectively 66 and 39 minutes. Overall mortality was 27.1%, including 38 early deaths (21.1%) and 12 late deaths (6.1%). The percentage of early death greatly decreased over the eras, from 42.1% in the seventies to 7.4% after 2010. Besides the earlier era of intervention (p < 0.0001), significant risk factors for death in multivariate analysis were preoperative pulmonary hypertension, acidosis, and cardiopulmonary bypass time. There were 24 reoperations, including 7 for pulmonary venous obstruction; 6 died. Factors directly and independently associated with late complications were the anatomic type (mixed forms, p = 0.0023), and length of aortic cross clamp time (p = 0.01). Long-term results for survivals are excellent. We report 84.7% of asymptomatic patients with a mean follow-up of 10.8 years.

Conclusions The overall prognosis of total anomalous pulmonary venous connection repair with conventional procedures has greatly improved over the years with excellent long-term results. A thorough evaluation of all preoperative characteristics is imperative to achieve the best outcome.