This Account provides an overview of our group’s research in the field of asymmetric
organocatalytic transformations generating chiral isoindolinone cores. We describe
the synthesis of 3-substituted 3-hydroxyisoindolinones as starting materials for these
transformations, comprising a wide range of functional groups, as well as their use
in asymmetric transformations. We also discuss our efforts in the application of the
developed methodology in the synthesis of a known HIV-1 inhibitor.
Key words
organocatalytic asymmetric transformations - 3-hydroxyisoindolinones - chiral Brønsted
acid - isoindolinone core - organometallic addition - chiral
N,
S-acetals
