The Transient Directing Group Strategy: A New Trend in Transition-Metal-Catalyzed C–H Bond Functionalization

Qun Zhao; Thomas Poisson; Xavier Pannecoucke; Tatiana Besset

doi:10.1055/s-0036-1590878

Synthesis, Table of Contents

Synthesis 2017; 49(21): 4808-4826
DOI: 10.1055/s-0036-1590878

short review

The Transient Directing Group Strategy: A New Trend in Transition-Metal-Catalyzed C–H Bond Functionalization

Authors

Qun Zhao

Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France Email: tatiana.besset@insa-rouen.fr
Thomas Poisson

Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France Email: tatiana.besset@insa-rouen.fr
Xavier Pannecoucke

Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France Email: tatiana.besset@insa-rouen.fr
Tatiana Besset*

Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France Email: tatiana.besset@insa-rouen.fr

Abstract

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Abstract

In recent years, the C–H bond activation field has known very fast expansion offering valuable synthetic tools. Consequently, the quest for new approaches to afford atom- and step-economical processes has driven the scientific community to imagine original strategies. In this context, the direct functionalization of substrates by a transition-metal-catalyzed C–H bond activation using a transient directing group has emerged as a promising approach. This short review focuses on the major progress made in this field to provide to the reader an overview of the recent advances.

1 Introduction

2 From a Historical Point of View

3 Functionalization of Carbonyl Derivatives

4 Functionalization of Amines Derivatives

5 Summary and Outlook

Key words

C–H bond functionalization - transient directing group - synthetic methods - dual catalysis - transition metals

Full Text

References

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