Semin Liver Dis 2017; 37(01): 033-044
DOI: 10.1055/s-0036-1597771
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

The Differentiation of Intestinal-Failure-Associated Liver Disease from Nonalcoholic Fatty Liver and Nonalcoholic Steatohepatitis

Alan L. Buchman
1   Department of Surgery, University of Illinois, Chicago, Illinois
,
Bita V. Naini
2   Department of Pathology, UCLA Medical Center, Los Angeles, California
,
Bert Spilker
3   Bert Spilker and Associates LLC, Bethesda, Maryland
› Author Affiliations
Further Information

Publication History

Publication Date:
15 February 2017 (online)

Preview

Abstract

Intestinal failure-associated liver disease (IFALD), formerly known as parenteral nutrition-associated liver disease has often been listed in textbooks as an example of nonalcoholic fatty liver disease (NAFLD). However, the etiology, pathophysiology, epidemiology, histology, and progression differ substantially between the conditions defined as NAFLD and the disease, IFALD. Therefore, IFALD should not be defined or considered as a type or a cause of nonalcoholic fatty liver or nonalcoholic steatohepatitis, but rather as a distinct disease.