Congenital Glioblastoma Multiforme: An Unusual and Challenging Tumor

Abstract

Congenital glioblastoma multiforme is a rare tumor of the central nervous system with unique features. The existing evidence on its pathogenesis, genetic and molecular profile, special characteristics, treatment, and prognosis is reviewed. An increased number of antenatal diagnoses and prolonged survival for those individuals who can tolerate combined surgical resection and chemotherapy has been noted. The overall prognosis, however, remains poor. A better understanding of this unusual entity is important. Further research is needed to discern tumor's pathogenesis and natural history. This will likely lead to the development and implementation of treatment strategies that may decrease mortality and morbidity in these patients.

Keywords

glioblastoma multiforme - congenital brain tumors - antenatal diagnosis - infancy - treatment - outcome

• References

• 1 Jurkiewicz E, Brożyna A, Grajkowska W. , et al. Congenital brain tumors in a series of 56 patients. Childs Nerv Syst 2012; 28 (08) 1193-1201
• 2 Boukas A, Panaretos P, Cowie C, Nicholson C, Jenkins A. Congenital glioblastoma multiforme: complete resection with long-term survival and a novel technique of contralateral cystoventriculostomy. Pediatr Neurosurg 2012; 48 (05) 327-330
• 3 Seker A, Ozek MM. Congenital glioblastoma multiforme. Case report and review of the literature. J Neurosurg 2006; 105 (6, Suppl): 473-479
• 4 Thankamony A, Harlow FH, Ponnampalam J, Clarke P. Congenital brain tumour mimicking fetal intracranial haemorrhage. J Obstet Gynaecol 2007; 27 (03) 314-317
• 5 Brat DJ, Shehata BM, Castellano-Sanchez AA. , et al. Congenital glioblastoma: a clinicopathologic and genetic analysis. Brain Pathol 2007; 17 (03) 276-281
• 6 Hou LC, Bababeygy SR, Sarkissian V. , et al. Congenital glioblastoma multiforme: case report and review of the literature. Pediatr Neurosurg 2008; 44 (04) 304-312
• 7 Sell M, Huber-Schumacher S, van Landeghem FK. Congenital glioblastoma multiforme with abnormal vascularity presenting as intracranial hemorrhage in prenatal ultrasound. Childs Nerv Syst 2006; 22 (07) 729-733
• 8 Macy ME, Birks DK, Barton VN. , et al. Clinical and molecular characteristics of congenital glioblastoma. Neuro-oncol 2012; 14 (07) 931-941
• 9 Lee DY, Kim YM, Yoo SJ. , et al. Congenital glioblastoma diagnosed by fetal sonography. Childs Nerv Syst 1999; 15 (04) 197-201
• 10 Nakayama K, Nakamura Y. Localization of congenital glioblastomas in the Japanese: a case report and review of the literature. Childs Nerv Syst 2002; 18 (3-4): 149-152
• 11 Winters JL, Wilson D, Davis DG. Congenital glioblastoma multiforme: a report of three cases and a review of the literature. J Neurol Sci 2001; 188 (1-2): 13-19
• 12 Manoranjan B, Provias JP. Congenital brain tumors: diagnostic pitfalls and therapeutic interventions. J Child Neurol 2011; 26 (05) 599-614
• 13 Wells HG. Occurrence and significance of congenital malignant neoplasms. Arch Pathol (Chic) 1940; 30:535-601
• 14 Solitare GB, Krigman MR. Congenital intracranial neoplasm. A case report and review of the literature. J Neuropathol Exp Neurol 1964; 23: 280-292
• 15 Wakai S, Arai T, Nagai M. Congenital brain tumors. Surg Neurol 1984; 21 (06) 597-609
• 16 Jellinger K, Sunder-Plassmann M. Connatal intracranial tumours. Neuropadiatrie 1973; 4 (01) 46-63
• 17 Bader A, Heran M, Dunham C, Steinbok P. Radiological features of infantile glioblastoma and desmoplastic infantile tumors: British Columbia's Children's Hospital experience. J Neurosurg Pediatr 2015; 16 (02) 119-125
• 18 Buetow PC, Smirniotopoulos JG, Done S. Congenital brain tumors: a review of 45 cases. AJR Am J Roentgenol 1990; 155 (03) 587-593
• 19 Carstensen H, Juhler M, Bøgeskov L, Laursen H. A report of nine newborns with congenital brain tumours. Childs Nerv Syst 2006; 22 (11) 1427-1431
• 20 Chuang YM, Guo WY, Ho DM. , et al. Skew ocular deviation: a catastrophic sign on MRI of fetal glioblastoma. Childs Nerv Syst 2003; 19 (5-6): 371-375
• 21 Donmez FY, Aslan H, Coban G, Ozen O, Agildere M. Multimodal MR imaging findings of a congenital glioblastoma multiforme. Childs Nerv Syst 2012; 28 (11) 1831-1833
• 22 Dören M, Tercanli S, Gullotta F, Holzgreve W. Prenatal diagnosis of a highly undifferentiated brain tumour--a case report and review of the literature. Prenat Diagn 1997; 17 (10) 967-971
• 23 Guibaud L, Champion F, Buenerd A, Pelizzari M, Bourgeois J, Pracros JP. Fetal intraventricular glioblastoma: ultrasonographic, magnetic resonance imaging, and pathologic findings. J Ultrasound Med 1997; 16 (04) 285-288
• 24 Ha H, Hong SM, Lee SK. , et al. Congenital desmoplastic cerebral glioblastoma: a case report. Korean J Pathol 2002; 36 (06) 440-444
• 25 Itoh Y, Kowada M, Mineura K, Kojima H. Congenital glioblastoma of the cerebellum with cytofluorometric deoxyribonucleic acid analysis. Surg Neurol 1987; 27 (02) 163-167
• 26 Jung WH, Choi S, Oh KK, Chi JG. Congenital glioblastoma multiforme--report of an autopsy case. J Korean Med Sci 1990; 5 (04) 225-231
• 27 Kamitomo M, Sameshima H, Uetsuhara K. , et al. Fetal glioblastoma: rapid growth during the third trimester. Fetal Diagn Ther 1998; 13 (06) 339-342
• 28 Kasliwal MK, Gupta DK, Mahapatra AK. , et al. Congenital gloiblastoma multiforme: a case report and review of the literature. J Pediatr Neurosci 2007; 2 (02) 69-71
• 29 Laure-Kamionowska M, Szymanska K, Biekiesinska-Figatowska M, Gierowska-Bogusz B, Michalak E, Klepacka T. Congenital glioblastoma coexisting with vascular developmental anomaly. Folia Neuropathol 2013; 51 (04) 333-339
• 30 Leins AM, Kainer F, Weis S. Sonography and neuropathology of a congenital brain tumor: report of a rare incident. Ultrasound Obstet Gynecol 2001; 17 (03) 245-247
• 31 Mazewski CM, Hudgins RJ, Reisner A, Geyer JR. Neonatal brain tumors: a review. Semin Perinatol 1999; 23 (04) 286-298
• 32 Mazzone D, Magro G, Lucenti A, Grasso S. Report of a case of congenital glioblastoma multiforme: an immunohistochemical study. Childs Nerv Syst 1995; 11 (05) 311-313
• 33 McConachie NS, Twining P, Lamb MP. Case report: antenatal diagnosis of congenital glioblastoma. Clin Radiol 1991; 44 (02) 121-122
• 34 Milano GM, Cerri C, Ferruzzi V. , et al. Congenital glioblastoma. Pediatr Blood Cancer 2009; 53 (01) 124-126
• 35 Morof DF, Levine D, Stringer KF, Grable I, Folkerth R. Congenital glioblastoma multiforme: prenatal diagnosis on the basis of sonography and magnetic resonance imaging. J Ultrasound Med 2001; 20 (12) 1369-1375
• 36 Shimamura N, Asano K, Ogane K, Yagihashi A, Ohkuma H, Suzuki S. A case of definitely congenital glioblastoma manifested by intratumoral hemorrhage. Childs Nerv Syst 2003; 19 (10-11): 778-781
• 37 Singhal RM, Jain M, Tanwar RK, Raman NV. Congenital glioblastoma. Indian J Pediatr 1994; 61 (06) 733-736
• 38 Davis T, Doyle H, Tobias V, Ellison DW, Ziegler DS. Case report of spontaneous resolution of a congenital glioblastoma. Pediatrics 2016; 137 (04) e20151241
• 39 Mandel VD, Persechino F, Berardi A. , et al. Congenital glioblastoma multiforme and eruptive disseminated Spitz nevi. Ital J Pediatr 2016; 42 (01) 47
• 40 Coccé MC, Mardin BR, Bens S. , et al. Identification of ZCCHC8 as fusion partner of ROS1 in a case of congenital glioblastoma multiforme with a t(6;12)(q21;q24.3). Genes Chromosomes Cancer 2016; 55 (09) 677-687
• 41 Gielen GH, Gessi M, Buttarelli FR. , et al. Genetic analysis of diffuse high-grade astrocytomas in infancy defines a novel molecular entity. Brain Pathol 2015; 25 (04) 409-417
• 42 Kotecha RS, Burley K, Junckerstorff RC. , et al. Chemotherapy increases amenability of surgical resection in congenital glioblastoma. Pediatr Hematol Oncol 2012; 29 (06) 538-544
• 43 Severino M, Schwartz ES, Thurnher MM, Rydland J, Nikas I, Rossi A. Congenital tumors of the central nervous system. Neuroradiology 2010; 52 (06) 531-548
• 44 Alifieris C, Trafalis DT. Glioblastoma multiforme: pathogenesis and treatment. Pharmacol Ther 2015; 152: 63-82
• 45 Parmar HA, Pruthi S, Ibrahim M, Gandhi D. Imaging of congenital brain tumors. Semin Ultrasound CT MR 2011; 32 (06) 578-589
• 46 Jhanwar-Uniyal M, Labagnara M, Friedman M, Kwasnicki A, Murali R. Glioblastoma: molecular pathways, stem cells and therapeutic targets. Cancers (Basel) 2015; 7 (02) 538-555
• 47 Young RM, Jamshidi A, Davis G, Sherman JH. Current trends in the surgical management and treatment of adult glioblastoma. Ann Transl Med 2015; 3 (09) 121
• 48 Hanaei S, Habibi Z, Nejat F, Sayarifard F, Vasei M. Pediatric glioblastoma multiforme in association with Turner's syndrome: a case report. Pediatr Neurosurg 2015; 50 (01) 38-41
• 49 Yang MM, Singhal A, Rassekh SR, Yip S, Eydoux P, Dunham C. Possible differentiation of cerebral glioblastoma into pleomorphic xanthoastrocytoma: an unusual case in an infant. J Neurosurg Pediatr 2012; 9 (05) 517-523
• 50 Phi JH, Koh EJ, Kim SK, Park SH, Cho BK, Wang KC. Desmoplastic infantile astrocytoma: recurrence with malignant transformation into glioblastoma: a case report. Childs Nerv Syst 2011; 27 (12) 2177-2181
• 51 Prakash V, Batanian JR, Guzman MA, Duncavage EJ, Geller TJ. Malignant transformation of a desmoplastic infantile ganglioglioma in an infant carrier of a nonsynonymous TP53 mutation. Pediatr Neurol 2014; 51 (01) 138-143
• 52 Sugimoto M, Kurishima C, Masutani S, Tamura M, Senzaki H. Congenital brain tumor within the first 2 months of life. Pediatr Neonatol 2015; 56 (06) 369-375
• 53 Van Poppel M, Klimo Jr P, Dewire M. , et al. Resection of infantile brain tumors after neoadjuvant chemotherapy: the St. Jude experience. J Neurosurg Pediatr 2011; 8 (03) 251-256
• 54 Rivero-Garvía M, Márquez-Rivas J, Rueda-Torres AB, Pascual-Argente D, Ramírez G. Treatment of glioblastoma multiforme with high doses of carmustine intracavitary, in an infant. Childs Nerv Syst 2012; 28 (05) 747-750
• 55 Grundy RG, Wilne SH, Robinson KJ. , et al; Children's Cancer and Leukaemia Group (formerly UKCCSG) Brain Tumour Committee. Primary postoperative chemotherapy without radiotherapy for treatment of brain tumours other than ependymoma in children under 3 years: results of the first UKCCSG/SIOP CNS 9204 trial. Eur J Cancer 2010; 46 (01) 120-133
• 56 Wisoff JH, Boyett JM, Berger MS. , et al. Current neurosurgical management and the impact of the extent of resection in the treatment of malignant gliomas of childhood: a report of the Children's Cancer Group trial no. CCG-945. J Neurosurg 1998; 89 (01) 52-59
• 57 Fisher PG. 50 years ago in the Journal of Pediatrics: brain tumors in early infancy--probably congenital in origin. J Pediatr 2014; 165 (05) 978
• 58 Lang SS, Beslow LA, Gabel B. , et al. Surgical treatment of brain tumors in infants younger than six months of age and review of the literature. World Neurosurg 2012; 78 (1-2): 137-144