Thorac cardiovasc Surg
DOI: 10.1055/s-0037-1602257
Original Cardiovascular
Georg Thieme Verlag KG Stuttgart · New York

Statin Therapy in Patients Undergoing Coronary Artery Bypass Grafting for Acute Coronary Syndrome

Oliver J. Liakopoulos1, Elmar W. Kuhn1, Ingo Slottosch1, Matthias Thielmann2, Daniel Wendt2, Kathrin Kuhr3, Heinz Jakob2, Thorsten Wahlers1, on behalf of the North-Rhine-Westphalia Study Group
  • 1Department of Cardiothoracic Surgery, Heart Center of the University Hospital of Cologne, Germany
  • 2Department of Thoracic and Cardiovascular Surgery, West German Heart Center, University of Duisburg-Essen, Germany
  • 3Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Germany
Further Information

Publication History

12 January 2017

13 March 2017

Publication Date:
20 April 2017 (eFirst)

Abstract

Background This study evaluates whether preoperative statin therapy improves clinical outcomes in patients referred to coronary artery bypass grafting (CABG) for acute coronary syndrome (ACS).

Methods A total of 1,151 patients undergoing CABG for ACS were prospectively entered into the North-Rhine-Westphalia surgical myocardial infarction registry and subdivided into two groups according to their preoperative statin status (statin naive vs. statin group). A logistic regression model was employed to analyze the impact of a statin therapy and dose for the endpoints in-hospital mortality and major adverse cardiac events (MACE).

Results Demographics, pre- and intraoperative data of the statin-naive group (n = 208; 18%) and statin-treated group (n = 943, 82%) did not differ. In-hospital mortality (12.6 vs. 6.3%, p = 0.002) and MACE rates (22.1 vs. 9.7%, p < 0.001) were significantly higher in statin naive when compared with statin-treated patients with ACS, respectively. Mevalonic acid revealed that both low- and high-dose statin treatment was associated to a reduction in in-hospital mortality and MACE, without a dose-dependent statin effect.

Conclusion Statin therapy in patients with ACS undergoing CABG reduces in a dose-independent manner in-hospital mortality and MACE.