Download PDF
Neuropediatrics 2017; 48(06): 463-466
DOI: 10.1055/s-0037-1603642
Short Communication
Georg Thieme Verlag KG Stuttgart · New York

Morning Glory Disc Anomaly Associated with Ipsilateral Optic Nerve and Chiasm Thickening: Three Cases and Review of the Literature

Chiara Doneda
1   Department of Pediatric Radiology and Neuroradiology, Children's Hospital V Buzzi, ASST. Fatebenefratelli Sacco, Milan, Italy
,
Lorenzo Pinelli
2   Department of Diagnostic Imaging, Neuroradiology Unit, Section of Pediatric Neuroradiology, ASST Spedali Civili, Brescia, Italy
,
Matteo Scaramuzzi
3   San Giuseppe Hospital, University Eye Clinic, Milan, Italy
4   Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
,
Jessica Galli
5   Unit of Child Neurology and Psychiatry, ASST Spedali Civili, Brescia, Italy
6   Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy
,
Elisa Fazzi
5   Unit of Child Neurology and Psychiatry, ASST Spedali Civili, Brescia, Italy
6   Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy
,
Cecilia Parazzini
1   Department of Pediatric Radiology and Neuroradiology, Children's Hospital V Buzzi, ASST. Fatebenefratelli Sacco, Milan, Italy
,
Andrea Righini
1   Department of Pediatric Radiology and Neuroradiology, Children's Hospital V Buzzi, ASST. Fatebenefratelli Sacco, Milan, Italy
,
Paolo Nucci
3   San Giuseppe Hospital, University Eye Clinic, Milan, Italy
4   Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
› Author Affiliations
Further Information

Publication History

29 November 2016

25 April 2017

Publication Date:
09 June 2017 (online)

    Permissions and Reprints

Abstract

Several extraorbital findings have been described in morning glory disc anomaly (MGDA), including optic pathway abnormalities. We want to emphasize the importance of looking for ipsilateral optic nerve and chiasm thickening in MGDA-affected patients because we think that it may be a relevant common associated finding to date not stressed by anyone. We report three cases of clinically diagnosed unilateral MGDA in which magnetic resonance imaging revealed enlargement of the ipsilateral optic nerve and chiasm. A literature analysis was made and previously reported MGDA cases, and case series were checked, looking for described, or misunderstood similar magnetic resonance imaging findings. Three other cases with very similar prechiasmatic optic nerve and chiasm findings were identified from the literature. Two further cases are discussed as possibly characterized by similar misinterpreted magnetic resonance features. Our study broadens the constellation of intra- and extraorbital findings of MGDA. Though magnetic resonance imaging is not sufficient to determine the neuropathological substrate of this finding, clinicians and radiologists should be aware of the possible association of MGDA with ipsilateral thickening of the optic nerve and chiasm, to properly plan the clinical and imaging follow-up.

Keywords

morning glory disc anomaly - optic nerve - MRI

Note

No grant support has been given for this study.


 

  • References

  • 1 Kindler P. Morning glory syndrome: unusual congenital optic disk anomaly. Am J Ophthalmol 1970; 69 (03) 376-384
    CrossrefPubMedGoogle Scholar
  • 2 Ellika S, Robson CD, Heidary G, Paldino MJ. Morning glory disc anomaly: characteristic MR imaging findings. AJNR Am J Neuroradiol 2013; 34 (10) 2010-2014
    CrossrefPubMedGoogle Scholar
  • 3 Auber AE, O'Hara M. Morning glory syndrome. MR imaging. Clin Imaging 1999; 23 (03) 152-158
    CrossrefPubMedGoogle Scholar
  • 4 Morioka M, Marubayashi T, Masumitsu T, Miura M, Ushio Y. Basal encephaloceles with morning glory syndrome, and progressive hormonal and visual disturbances: case report and review of the literature. Brain Dev 1995; 17 (03) 196-201
    CrossrefPubMedGoogle Scholar
  • 5 Dutton GN. Congenital disorders of the optic nerve: excavations and hypoplasia. Eye (Lond) 2004; 18 (11) 1038-1048
    CrossrefPubMedGoogle Scholar
  • 6 Haik BG, Greenstein SH, Smith ME, Abramson DH, Ellsworth RM. Retinal detachment in the morning glory anomaly. Ophthalmology 1984; 91 (12) 1638-1647
    CrossrefPubMedGoogle Scholar
  • 7 Lenhart PD, Lambert SR, Newman NJ. , et al. Intracranial vascular anomalies in patients with morning glory disk anomaly. Am J Ophthalmol 2006; 142 (04) 644-650
    CrossrefPubMedGoogle Scholar
  • 8 Pierre-Filho PdeT, Limeira-Soares PH, Marcondes AM. Morning glory syndrome associated with posterior pituitary ectopia and hypopituitarism. Acta Ophthalmol Scand 2004; 82 (01) 89-92
    CrossrefPubMedGoogle Scholar
  • 9 Minotto I, Abdala N, Miachon AA, Spinola e Castro AM, Imamura P, Nogueira RG. Basal encephalocele associated with morning glory syndrome: case report. Arq Neuropsiquiatr 2007; 65 (4A): 988-991
    CrossrefPubMedGoogle Scholar
  • 10 Ceynowa DJ, Wickström R, Olsson M. , et al. Morning glory disc anomaly in childhood - a population-based study. Acta Ophthalmol 2015; 93 (07) 626-634
    CrossrefPubMedGoogle Scholar
  • 11 Bandopadhayay P, Dagi L, Robison N, Goumnerova L, Ullrich NJ. Morning glory disc anomaly in association with ipsilateral optic nerve glioma. Arch Ophthalmol 2012; 130 (08) 1082-1083
    CrossrefPubMedGoogle Scholar
  • 12 Traboulsi EI. Morning glory disk anomaly--more than meets the eye. J AAPOS 2009; 13 (04) 333-334
    CrossrefPubMedGoogle Scholar
  • 13 Manschot WA. Morning glory syndrome: a histopathological study. Br J Ophthalmol 1990; 74 (01) 56-58
    CrossrefPubMedGoogle Scholar
  • 14 Poukens V, Glasgow BJ, Demer JL. Nonvascular contractile cells in sclera and choroid of humans and monkeys. Invest Ophthalmol Vis Sci 1998; 39 (10) 1765-1774
    PubMedGoogle Scholar
  • 15 Borghei-Razavi H, Shibao S, Schick U. Prechiasmatic transection of the optic nerve in optic nerve glioma: technical description and surgical outcome. Neurosurg Rev 2017; 40 (01) 135-141
    CrossrefPubMedGoogle Scholar
  • 16 Wan MJ, Ullrich NJ, Manley PE, Kieran MW, Goumnerova LC, Heidary G. Long-term visual outcomes of optic pathway gliomas in pediatric patients without neurofibromatosis type 1. J Neurooncol 2016; 129 (01) 173-178
    CrossrefPubMedGoogle Scholar
  • 17 Ottenhausen M, Bittigau P, Koch A, Lankes E, Schulz M, Thomale UW. Hamartoma of the optic nerve in a young child—case report and review of the literature. Childs Nerv Syst 2015; 31 (08) 1401-1406
    CrossrefPubMedGoogle Scholar
  • 18 Giannini C, Reynolds C, Leavitt JA. , et al. Choristoma of the optic nerve: case report. Neurosurgery 2002; 50 (05) 1125-1128
    PubMedGoogle Scholar
  • 19 Spencer A, Lee J, Prayson RA. Optic nerve choristoma. Ann Diagn Pathol 2005; 9 (02) 93-95
    CrossrefPubMedGoogle Scholar