Semin Liver Dis 2017; 37(03): 243-258
DOI: 10.1055/s-0037-1603651
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Quantitative Imaging in Diffuse Liver Diseases

Bernard E. Van Beers1, 2, Philippe Garteiser1, Benjamin Leporq1, Pierre-Emmanuel Rautou3, 4, Dominique Valla3, 4
  • 1Laboratory of Imaging Biomarkers, Inflammation Research Center, UMR 1149 INSERM - University Paris Diderot, Paris, France
  • 2Department of Radiology, DHU Unity, Beaujon University Hospital Paris Nord, Clichy, France
  • 3Inflammation Research Center, UMR 1149 INSERM - University Paris Diderot, Paris, France
  • 4Department of Hepatology, DHU Unity, Beaujon University Hospital Paris Nord, Clichy, France
Further Information

Publication History

Publication Date:
28 August 2017 (online)

Abstract

Cross-sectional imaging methods and more specifically ultrasonography and magnetic resonance imaging (MRI), have increasing roles in the quantitative evaluation of diffuse liver diseases. Particularly, ultrasound elastography is becoming the standard first-line examination for diagnosing severe liver fibrosis. Quantitative ultrasonography also brings information for staging portal hypertension in compensated cirrhosis and for grading liver steatosis. Quantitative MRI offers a multiparametric approach to assess the severity of liver steatosis, iron overload, fibrosis, inflammation, and portal hypertension. Regional liver transport function can be assessed with combined volumetric computed tomography and 99Tc mebrofenin single-photon emission computed tomography or with gadoxetic acid-enhanced MRI. It is concluded that multiparametric MRI complements the information brought with quantitative ultrasonography and has the potential to become a method of virtual liver biopsy that may decrease the need for invasive reference examinations in diffuse liver diseases.