Semin Respir Crit Care Med 2017; 38(04): 532-537
DOI: 10.1055/s-0037-1603768
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Sarcoidosis: Drugs under Investigation

Jonas Christian Schupp
Department of Pneumology, Medical Center - University of Freiburg, Medical Faculty, University of Freiburg, Germany
Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut
,
Björn Christian Frye
Department of Pneumology, Medical Center - University of Freiburg, Medical Faculty, University of Freiburg, Germany
,
Gernot Zissel
Department of Pneumology, Medical Center - University of Freiburg, Medical Faculty, University of Freiburg, Germany
,
Joachim Müller-Quernheim
Department of Pneumology, Medical Center - University of Freiburg, Medical Faculty, University of Freiburg, Germany
› Author Affiliations
Further Information

Publication History

Publication Date:
27 July 2017 (online)

Abstract

Etiology of sarcoidosis is still elusive, yet there has been considerable progress in various areas of basic and clinical research. In this review, we focus on ongoing or recently completed clinical–pharmacological studies in patients with sarcoidosis. Positive studies were published in well-characterized and homogenous subcohorts of sarcoid patients. Several drugs have shown a positive effect on sarcoidosis-associated fatigue, cutaneous sarcoidosis, and pulmonary hypertension in sarcoid patients. It seems that the recruitment of clinically precisely defined subcohorts is necessary to achieve positive outcomes in studies on sarcoidosis.