Etiology and Perinatal Outcome of Nonimmune Hydrops Fetalis in Southern China

Sheng He; Linlin Wang; Pingshan Pan; Hongwei Wei; Dahua Meng; Juan Du; Xiaoxian Tian; Chenguang Zheng; Xiaoxia Qiu; Guoyang Luo

doi:10.1055/s-0037-1603890

American Journal of Perinatology Reports, Inhaltsverzeichnis

CC-BY-NC-ND 4.0 · AJP Rep 2017; 07(02): e111-e115
DOI: 10.1055/s-0037-1603890

Case Report

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Etiology and Perinatal Outcome of Nonimmune Hydrops Fetalis in Southern China

Authors

Sheng He^*

¹Prenatal Diagnosis Center, Guangxi Zhuang Autonomous Region Women and Children Care Hospital, Nanning, People's Republic of China
Linlin Wang^*

¹Prenatal Diagnosis Center, Guangxi Zhuang Autonomous Region Women and Children Care Hospital, Nanning, People's Republic of China
Pingshan Pan

¹Prenatal Diagnosis Center, Guangxi Zhuang Autonomous Region Women and Children Care Hospital, Nanning, People's Republic of China
Hongwei Wei

¹Prenatal Diagnosis Center, Guangxi Zhuang Autonomous Region Women and Children Care Hospital, Nanning, People's Republic of China
Dahua Meng

¹Prenatal Diagnosis Center, Guangxi Zhuang Autonomous Region Women and Children Care Hospital, Nanning, People's Republic of China
Juan Du

¹Prenatal Diagnosis Center, Guangxi Zhuang Autonomous Region Women and Children Care Hospital, Nanning, People's Republic of China
Xiaoxian Tian

¹Prenatal Diagnosis Center, Guangxi Zhuang Autonomous Region Women and Children Care Hospital, Nanning, People's Republic of China
Chenguang Zheng

¹Prenatal Diagnosis Center, Guangxi Zhuang Autonomous Region Women and Children Care Hospital, Nanning, People's Republic of China
Xiaoxia Qiu

¹Prenatal Diagnosis Center, Guangxi Zhuang Autonomous Region Women and Children Care Hospital, Nanning, People's Republic of China
Guoyang Luo

²Department of Obstetrics and Gynecology, University of Connecticut, Farmington, Connecticut

Abstract

Objective This study aims to analyze the etiology and perinatal outcome of nonimmune hydrops fetalis (NIHF) in Southern China.

Methods All cases with NIHF diagnosed antenatally from January 1, 2007 to December 31, 2014 were identified and analyzed.

Results Total 482 cases of NIHF were identified during the study period. The most common cause of NIHF was hemoglobin (Hb) Bart's disease (61.8%), followed by chromosomal abnormalities (13.5%), idiopathic etiology (13.1%), cardiac abnormalities (6.4%), and others (5.2%). After 20 weeks' gestation, a total of 408 cases of NIHF presented, including Hb Bart's disease (279 cases), cardiac abnormalities (27 cases), and infection (7 cases). NIHF caused by chromosomal abnormalities mainly presented between 15 and 19 weeks' gestation. Of the 482 cases, 459 cases elected termination of pregnancy. The remaining 23 cases elected to continue their pregnancy. Among them, 14 (60.9%) resulted in intrauterine fetal death, 6 had neonatal death, 3 infants survived to 1 year of age. Of the three infants, one has cerebral palsy, and the remaining two are normal.

Conclusions Hb Bart's disease is the most common cause of NIHF in Southern China. An effective prenatal screening and counseling program for thalassemia in this region may be the most effective way to lower the incidence NIHF.

Keywords

nonimmune hydrops fetalis - NIHF - causes - Hb Bart's disease - thalassemia

Volltext

Referenzen

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