Abstract
Cytokines are a very important part in the regulation of immune response in sepsis.
They are cellular signaling proteins whose production is a result of activation of
specific receptors. Variations in the genes encoding cytokines have a significant
role in interindividual susceptibility to sepsis and its severity, and their function
may be modulated by age, gender, and some environmental factors. Cytokines are classified
into the subsets of proinflammatory, anti-inflammatory, and multiple function cytokines.
Regulated balance between proinflammatory cytokines, anti-inflammatory cytokines,
and soluble inhibitors of proinflammatory cytokines is important for eliminating pathogens
and reducing inflammation. High levels of some cytokines, such as tumor necrosis factor-α,
interleukin (IL)-1, and IL-6, determine the course of disease and outcome in sepsis.
Likewise, numerous other biomarkers may be potential indicators of sepsis, but none
has been routinely used. The best approach to the diagnosis of sepsis is the combination
of different biomarkers.
Keywords
sepsis - immune response - cytokines - other biomarkers
