CC-BY 4.0 · Semin Thromb Hemost
DOI: 10.1055/s-0037-1604108
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

To What Extent Are the Terminal Stages of Sepsis, Septic Shock, Systemic Inflammatory Response Syndrome, and Multiple Organ Dysfunction Syndrome Actually Driven by a Prion/Amyloid Form of Fibrin?

Douglas B. Kell1, 2, 3, Etheresia Pretorius4
  • 1School of Chemistry, The University of Manchester, Manchester, United Kingdom
  • 2Manchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom
  • 3Centre for Synthetic Biology of Fine and Speciality Chemicals, The University of Manchester, Manchester, United Kingdom
  • 4Department of Physiological Sciences, Stellenbosch University, Matieland, South Africa
Further Information

Publication History

Publication Date:
04 August 2017 (eFirst)

Abstract

A well-established development of increasing disease severity leads from sepsis through systemic inflammatory response syndrome, septic shock, multiple organ dysfunction syndrome, and cellular and organismal death. Less commonly discussed are the equally well-established coagulopathies that accompany this. We argue that a lipopolysaccharide-initiated (often disseminated intravascular) coagulation is accompanied by a proteolysis of fibrinogen such that formed fibrin is both inflammatory and resistant to fibrinolysis. In particular, we argue that the form of fibrin generated is amyloid in nature because much of its normal α-helical content is transformed to β-sheets, as occurs with other proteins in established amyloidogenic and prion diseases. We hypothesize that these processes of amyloidogenic clotting and the attendant coagulopathies play a role in the passage along the aforementioned pathways to organismal death, and that their inhibition would be of significant therapeutic value, a claim for which there is considerable emerging evidence.

Ethical Approval Disclosure

Ethical approval was granted by the University of Pretoria for all human studies (Human Ethics Committee: Faculty of Health Sciences) to Etheresia Pretorius.


Funding

We thank the Biotechnology and Biological Sciences Research Council (grant BB/L025752/1) as well as the National Research Foundation (NRF) and Medical Research Council (MRC) of South Africa for supporting this collaboration.