Semin intervent Radiol 2017; 34(03): 288-293
DOI: 10.1055/s-0037-1604300
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Outcomes of Venous Malformation Sclerotherapy: A Review of Study Methodology and Long-Term Results

Sumera Ali
1   Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas
,
Sally E. Mitchell
2   Division of Interventional Radiology, Johns Hopkins Medicine, Baltimore, Maryland
› Author Affiliations
Further Information

Publication History

Publication Date:
11 September 2017 (online)

Abstract

It is very important that patients seeking sclerotherapy for the treatment of venous malformations are aware of the expected course of the therapy. They should be thoroughly counseled about the complications, the need for multiple sessions of therapy, and also about the expected clinical outcome. The aim of this review is to discuss the long-term outcomes of sclerotherapy for the treatment of venous malformation. Many studies have discussed their individual center's experiences and short-midterm results, but there is a relative paucity of data on long-term outcomes. We have reviewed the literature and also shared our experience of a large cohort of patients (n = 116) with a relatively longer follow-up period of more than 1 year. Venous malformations are very complex lesions and their treatment is quite variable depending on its extent and complexity. As a result, outcome studies vary considerably in the choice of sclerosant, study methodology, outcome assessment (clinical vs. imaging), and grading scales. This review also highlights this extreme heterogeneity in the literature of the sclerotherapy outcome and summarizes a few national and international studies for comparison.

 
  • References

  • 1 Limaye N, Wouters V, Uebelhoer M. , et al. Somatic mutations in angiopoietin receptor gene TEK cause solitary and multiple sporadic venous malformations. Nat Genet 2009; 41 (01) 118-124
  • 2 Castillo SD, Tzouanacou E, Zaw-Thin M. , et al. Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans. Sci Transl Med 2016; 8 (332) 332ra43
  • 3 Zhang J, Li HB, Zhou SY. , et al. Comparison between absolute ethanol and bleomycin for the treatment of venous malformation in children. Exp Ther Med 2013; 6 (02) 305-309
  • 4 Burrows PE, Mason KP. Percutaneous treatment of low flow vascular malformations. J Vasc Interv Radiol 2004; 15 (05) 431-445
  • 5 Jin Y, Lin X, Li W, Hu X, Ma G, Wang W. Sclerotherapy after embolization of draining vein: a safe treatment method for venous malformations. J Vasc Surg 2008; 47 (06) 1292-1299
  • 6 Schumacher M, Dupuy P, Bartoli JM. , et al. Treatment of venous malformations: first experience with a new sclerosing agent--a multicenter study. Eur J Radiol 2011; 80 (03) e366-e372
  • 7 Dompmartin A, Blaizot X, Théron J. , et al. Radio-opaque ethylcellulose-ethanol is a safe and efficient sclerosing agent for venous malformations. Eur Radiol 2011; 21 (12) 2647-2656
  • 8 Yamaki T, Nozaki M, Sakurai H, Takeuchi M, Soejima K, Kono T. Prospective randomized efficacy of ultrasound-guided foam sclerotherapy compared with ultrasound-guided liquid sclerotherapy in the treatment of symptomatic venous malformations. J Vasc Surg 2008; 47 (03) 578-584
  • 9 Ali S, Weiss CR, Sinha A, Eng J, Mitchell SE. The treatment of venous malformations with percutaneous sclerotherapy at a single academic medical center. Phlebology 2016; 31 (09) 603-609
  • 10 van der Linden E, Pattynama PM, Heeres BC, de Jong SC, Hop WC, Kroft LJ. Long-term patient satisfaction after percutaneous treatment of peripheral vascular malformations. Radiology 2009; 251 (03) 926-932
  • 11 Goyal M, Causer PA, Armstrong D. Venous vascular malformations in pediatric patients: comparison of results of alcohol sclerotherapy with proposed MR imaging classification. Radiology 2002; 223 (03) 639-644
  • 12 Caty V, Kauffmann C, Dubois J. , et al. Clinical validation of semi-automated software for volumetric and dynamic contrast enhancement analysis of soft tissue venous malformations on magnetic resonance imaging examination. Eur Radiol 2014; 24 (02) 542-551
  • 13 Spence J, Krings T, terBrugge KG, da Costa LB, Agid R. Percutaneous sclerotherapy for facial venous malformations: subjective clinical and objective MR imaging follow-up results. AJNR Am J Neuroradiol 2010; 31 (05) 955-960
  • 14 Tan KT, Kirby J, Rajan DK, Hayeems E, Beecroft JR, Simons ME. Percutaneous sodium tetradecyl sulfate sclerotherapy for peripheral venous vascular malformations: a single-center experience. J Vasc Interv Radiol 2007; 18 (03) 343-351
  • 15 Lee BB, Do YS, Byun HS, Choo IW, Kim DI, Huh SH. Advanced management of venous malformation with ethanol sclerotherapy: mid-term results. J Vasc Surg 2003; 37 (03) 533-538