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Semin Respir Crit Care Med 2017; 38(06): 821-829
DOI: 10.1055/s-0037-1608772
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Management of Cerebral Edema in Acute Liver Failure

Beverley Kok
1   Division of Gastroenterology (Liver Unit), Department of Critical Care Medicine, University of Alberta, Edmonton, Canada
,
Constantine J. Karvellas
1   Division of Gastroenterology (Liver Unit), Department of Critical Care Medicine, University of Alberta, Edmonton, Canada
› Author Affiliations
Further Information

Publication History

Publication Date:
20 December 2017 (online)

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Abstract

Advances in medical care of the acute liver failure patient have led to a significant reduction in mortality related to the condition. Nevertheless, cerebral edema and ensuing brain herniation remains one of the top causes of demise in acute liver failure. Controversy remains regarding the utility of invasive intracranial pressure monitoring as well as usage of novel treatment modalities including therapeutic hypothermia. This review provides a brief summary into the pathophysiology and risk factors for developing cerebral edema in the context of acute liver failure; this review particularly provides a practical focus on general management of the patient with established cerebral edema as well as specific intracranial pressure-lowering strategies.

Keywords

acute liver failure - intracranial hypertension - cerebral edema - neuroprotection - therapeutic hypothermia

Financial Support

None.


 

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