J Neurol Surg B 2018; 79(04): 379-385
DOI: 10.1055/s-0037-1609033
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Importance of Frontal Horn Ratio and Optimal CSF Drainage in the Treatment of Very Low-Pressure Hydrocephalus

Danielle Houlden
1  McGill University, Avenue Henri-Julien, Montreal, Quebec, Canada
,
Dmitriy Khodorskiy
2  Department of Gastroenterology, Maimonides Medical Center, Brooklyn, New York, United States
,
Sandra Miller-Portman
3  Neurogens Clinical and Research Consultation, Atlanta, Georgia, United States
,
Maria Li
4  Department of Surgery, Université de Montreal, Montreal, Quebec, Canada
› Author Affiliations
Further Information

Publication History

31 January 2017

13 October 2017

Publication Date:
11 December 2017 (eFirst)

Abstract

Introduction Unlike low-pressure hydrocephalus, very low pressure hydrocephalus (VLPH) is a rarely reported clinical entity previously described to be associated with poor outcomes and to be possibly refractory to treatment with continued cerebrospinal fluid (CSF) drainage at subatmospheric pressures.1, 2 We present four cases of VLPH following resection of suprasellar lesions and hypothesize that untreatable patients can be identified early, thereby avoiding futile prolonged external ventricular drainage in ICU.

Methods We performed a retrospective chart review of four cases of VLPH encountered between 2007 and 2015 in two different institutions and practices and tried to identify factors contributing to successful treatment. We hypothesized that normalization of frontal horn ratio (FHR), optimization of volume of CSF drained, and avoidance of fluid shifts would contribute to improved Glasgow Coma Score (GCS). We examined fluid shifts by studying net fluids shifts and serum levels of sodium, urea, and creatinine. We used Pearson and Spearman correlations to identify measures that would correlate with improved GCS.

Results Our study reveals that improving GCS is positively correlated with decreased FHR and increased CSF drainage within an optimal range. The most important determinant of good outcome is retention of brain viscoelasticity as evidenced by restoration and maintenance of good GCS score despite fluctuations in FHR.

Conclusion Futile prolonged subatmospheric drainage can be avoided by declining to continue treatment in patients who have permanently altered brain compliance secondary to unsealed CSF leaks, irremediable ventriculitis, and who are therefore unable to sustain an improved neurologic examination.