Studies towards the Synthesis of the Antibiotic Tetrodecamycin

Abstract

A study towards the natural product tetrodecamycin is reported. A modified Schlosser–Wittig reaction was utilized to prepare the precursor for the subsequent intramolecular Diels–Alder reaction, which delivered the trans-decalin ring of the natural product. The tetronic­ acid moiety of the molecule was prepared by a Dieckmann cyclization­. The cyclization of the tetronic acid to the trans-decalin double­ bond to form a seven-membered ring was examined.

Key words

Schlosser–Wittig reaction - intramolecular Diels–Alder reaction­ - aldol reaction - Dieckmann cyclization - tetronic acid

• References and Notes

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