Abstract
Oxindoles represent an important class of bioactive compounds and synthetic derivatives
found in many natural products. Most of these compounds are chiral molecules and the
challenge of their asymmetric synthesis has fascinated many research groups. In particular,
the creation of chiral centers out of the oxindole ring by vinylogous addition to
3-alkylidene-substituted oxindoles (3-alkylidene-1,3-dihydro-2H-indol-2-ones) has emerged in recent years. This review aims to give an overview of
this topic.
1 Introduction
2 Aldol and Mannich Reactions
3 Addition to Unsaturated Carbonyl Compounds
4 Addition to Nitroalkenes
5 Miscellaneous
6 Conclusion
Key words
oxindole - vinylogous reactions - asymmetric synthesis - organocatalysis - metal catalysis
