Electrophilic Activation of Amides for the Preparation of Poly­substituted Pyrimidines

^◊ These authors contributed equally.

Published as part of the 50 Years SYNTHESIS – Golden Anniversary Issue

Abstract

In this article we describe the straightforward synthesis of polysubstituted pyrimidines by electrophilic activation of secondary amides in the presence of alkynes. An unusual mechanistic detour leading to pyridine derivatives as products is also presented and briefly discussed.

Key words

pyrimidines - amide activation - hydride shift - pyridines

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