One-Pot Approach for S_NAr Reaction of Fluoroaromatic Compounds with Cyclopropanol

Abstract

A novel method for preparing aromatic compounds containing cyclopropoxy via nucleophilic aromatic substitution reaction (S_NAr) of fluoroaromatic compounds with cyclopropanol under relatively mild conditions is presented. As compared to the approaches reported previously for preparing 1-(cyclopropyloxy)-2-nitrobenzene, the one proposed in this work is simplified without sacrificing the yields: When the reaction was performed at 75 °C with Cs₂CO₃ as the base and DMF as solvent, after 6 h the yield was up to 90%. Finally, various fluoroaromatic compounds were employed as substrates for a test that proves a wide application scope of the method.

Key words

fluoroaromatic compounds - nucleophilic aromatic substitution reaction (S_NAr) - cyclopropanol - Cs₂CO₃ - DMF

• References and Notes

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