Factor XII-dependent Contact Activation on Endothelial Cells and Binding Proteins gC1qR and Cytokeratin 1

Kusumam Joseph; Yoji Shibayama; Berhane Ghebrehiwet; Allen P. Kaplan

doi:10.1055/s-0037-1612914

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2001; 85(01): 119-124
DOI: 10.1055/s-0037-1612914

Review Article

Schattauer GmbH

Factor XII-dependent Contact Activation on Endothelial Cells and Binding Proteins gC1qR and Cytokeratin 1

Kusumam Joseph

¹Department of Medicine, Division of Pulmonary and Critical Care, Allergy and Clinical Immunology and Konishi-MUSC Institute for Inflammation Research, Medical University of South Carolina, Charleston, SC, USA

,

Yoji Shibayama

²Nippon Zoki Institute of Bioactive Science, Hyogo, Japan

,

Berhane Ghebrehiwet

³Department of Medicine, Suny-Stony Brook, NY, USA

,

Allen P. Kaplan

¹Department of Medicine, Division of Pulmonary and Critical Care, Allergy and Clinical Immunology and Konishi-MUSC Institute for Inflammation Research, Medical University of South Carolina, Charleston, SC, USA

› Author Affiliations

Abstract

Summary

Although proteins of the kinin-forming pathway are bound along the surface of endothelial cells, the mechanism of activation of this proteolytic cascade is unclear. Endothelial cell surface proteins, gC1qR and cytokeratin 1, are capable of binding Factor XII and high molecular weight kininogen (HK) in a zinc-dependent reaction thus we considered the possibility that these proteins might catalyze initiation of the cascade. Incubation of Factor XII, prekallikrein, and HK with gC1qR or cytokeratin 1 leads to a zinc-dependent and Factor XII-dependent conversion of prekallikrein to kallikrein. We also demonstrate that normal plasma is capable of activating upon interaction with the cells whereas plasma deficient in Factor XII, prekallikrein and HK do not activate. Normal plasma activation was inhibitable by antibody to gC1qR and cytokeratin 1. Thus, gC1qR and cytokeratin 1, represent potential initiating surfaces for activation of the plasma kinin-forming cascade and may do so as a result of their expression along cell surfaces.

Keywords

Factor XII - HK - gC1qR - cytokeratin 1 - endothelial cells

Full Text

References

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