FXI Is Essential for Thrombus Formation Following FeCl3-Induced Injury of the Carotid Artery in the Mouse

Thromb Haemost 2002; 87(04): 774-776
DOI: 10.1055/s-0037-1613081

Letters to the Editor

Schattauer GmbH

FXI Is Essential for Thrombus Formation Following FeCl₃-Induced Injury of the Carotid Artery in the Mouse

Elliot D. Rosen

¹W. M. Keck Center for Transgene Research and the Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame. IN, USA

,

Dave Gailani

¹W. M. Keck Center for Transgene Research and the Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame. IN, USA

,

Francis J. Castellino

¹W. M. Keck Center for Transgene Research and the Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame. IN, USA

References
1 Gailani D, Broze Jr GJ. Factor XI activation in a revised model of blood coagulation. Science 1991; 253 (5022): 909-12.
2 Gialani D, Broze Jr GJ. Factor XI activation by thrombin and factor XIa. Semin Thromb Hemost 1993; 19 (04) 396-404.
3 Walsh PN. Roles of platelets and factor XI in the initiation of blood coagulation by thrombin. Thromb Haemost 2001; 86 (01) 75-82.
4 Gailani D. et al. Model for a factor IX activation complex on blood platelets: dimeric conformation of factor XIa is essential. Blood 2001; 97 (10) 3117-22.
5 Gialani D, Lasky NM, Broze Jr GJ. A murine model of factor XI deficiency. Blood Coagul Fibrinolysis 1997; 08 (02) 134-44.
6 Rosen ED. et al. Laser-induced noninvasive vascular injury models in mice generate platelet- and coagulation-dependent thrombi. Am J Pathol 2001; 185 (05) 1613-22.
7 Farrehi PM. et al. Regulation of arterial thrombolysis by plasminogen activator inhibitor-1 in mice. Circulation 1998; 97 (10) 1002-8.