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Thromb Haemost 2002; 87(06): 953-958
DOI: 10.1055/s-0037-1613117
Review Article
Schattauer GmbH

Tissue Factor Expression on Monocyte Subpopulations during Normal Pregnancy

Valerie A. Holmes
1   Northern Ireland Centre for Diet and Health (NICHE), University of Ulster, Coleraine
3   Department of Haematology, Belfast City Hospital, Belfast, UK
,
Julie M. W. Wallace
1   Northern Ireland Centre for Diet and Health (NICHE), University of Ulster, Coleraine
,
W. S. Gilmore
1   Northern Ireland Centre for Diet and Health (NICHE), University of Ulster, Coleraine
,
P. McFaul
2   Department of Obstetrics and Gynaecology
,
H. D. Alexander
3   Department of Haematology, Belfast City Hospital, Belfast, UK
› Author Affiliations
Further Information

Publication History

Received 10 August 2001

Accepted after resubmission 13 February 2002

Publication Date:
08 December 2017 (online)

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Summary

Pregnancy is often referred to as a hypercoagulable state due to changes in the haemostatic system. Tissue factor (TF) is the initiator of blood clotting in vivo. The effect of pregnancy on monocyte TF expression was determined in a longitudinal case control study (89 pregnant, 39 non-pregnant). Using whole blood flow cytometry and CD14 as a monocyte marker, TF expression was measured on all CD14 positive, CD14Bright and CD14Dim cells. TF expression was significantly lower in pregnant women than in non-pregnant control subjects, on all CD14 positive cells at 20 and 35 weeks, on CD14Bright cells at 12 and 35 weeks and on CD14Dim cells at 20 weeks. Additionally, we report that a higher percentage of CD14Dim than CD14Bright cells express TF. These results suggest that, in order to maintain homeostasis in haemostasis in an otherwise hypercoagulable state, monocyte TF expression is reduced during normal pregnancy.

Keywords

Pregnancy - tissue factor - monocyte - flow cytometry - haemostasis
 

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