Hyperhomocysteinemia, MTHFR C 677T Genotype and Low Folate Levels: A Risk Combination for Acute Coronary Disease in a Portuguese Population

• References

• 1 Araujo F, Santos A, Araujo V, Henriques I, Monteiro F, Meireles E, Moreira I, David D, Maciel MJ, Cunha-Ribeiro LM. Genetic risk factors in acute coronary disease. Haemostasis. 1999 (in press).
• 2 Brattstrom L, Wilcken DE, Ohrvik J, Brudin L. Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis. Circulation 1998; 98: 2520-6.
• 3 Kluijtmans LAK, Kastelein JJP, Lindermans J, Boers GHJ, Heil SG, Bruschke AVG, Jukema JW, van den Heuvel LPWJ, Trijbels FJM, Boerma GJM, Verheugt FWA, Willems F, Blom HJ. Thermolabile methylenetetrahydrofolate reducatse in coronary artery disease. Circulation 1997; 96: 2573-7.
• 4 Cattaneo M. Hyperhomocysteinemia, atherosclerosis and thrombosis. Thromb Haemost 1999; 81: 165-76.
• 5 Arruda VR, von Zuben PM, Chiapani LC, Annichino-Bizzachi JM, Costa FF. The mutation Ala677-Val in the methylene tetrahydrofolate reductase gene: a risk factor for arterial disease and venous thrombosis. Thromb Haemost 1997; 77: 818-21.