No Evidence for Enhanced Thrombin Formation through Displacement of Annexin V by Antiphospholipid Antibodies

• References

• 1 Hughes GRV. Hughes’ syndrome: the antiphospholipid syndrome. A historical view. Lupus 1998; 07 (Suppl. 02) S1-S4.
• 2 Rand JH, Wu XX, Giessen P. A possible solution to the paradox of the “Lupus Anticoagulant”: Antiphospholipid antibodies accelerate thrombin generation by inhibiting Annexin-V. Thromb Haemost 1999; 82: 1376-7.
• 3 Rand JH, Wu XX, Andree HAM, Lockwood CJ, Guller S, Scher J, Harpel PC. Pregnancy loss in the antiphospholipid syndrome – a possible thrombogenic mechanism. N Engl J Med 1997; 337: 154-60.
• 4 Rand JH, Wu XX, Andreee HAM. et al. Antiphospholipid antibodies accelerate plasma coagulation by inhibiting annexin-V binding to phospholipids: A “lupus procoagulant” phenomenon. Blood 1998; 92 (05) 1652-60.
• 5 Sammaritano LR, Gharavi AE, Soberano C, Levy RA, Lockshin MD. Phospholipid binding of antiphospholipid antibodies and placental anticoagulant protein. J Clin Immunol 1992; 12 no. 1 27-35.
• 6 Willems GM, Janssen MP, Comfurius P, Galli M, Zwaal RFA, Bevers EM. Competition of annexin V and anticardiolipin antibodies for binding to phosphatidylserine containing bilayers. Biochemistry 2000; 39: 1982-9.
• 7 Bevers EM, Comfurius P, Zwaal RFA. Changes in membrane phospholipid distribution during platelet activation. Biochim Biophys Acta 1983; 736: 57-66.