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Thromb Haemost 2000; 84(01): 27-31
DOI: 10.1055/s-0037-1613962
DOI: 10.1055/s-0037-1613962
Commentary
Homocysteine as a Risk Factor for Restenosis after Coronary Angioplasty
Authors
This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture, Japan; the Japan Cardiovascular Research Foundation; TMFC; the Suzuken Memorial Foundation; the Ryoichi Naito Foundation for Medical Research; the Tokyo Biochemical Research Foundation; and the Mochida Memorial Foundation for Medical and Pharmaceutical Research (to H. Kurihara); and by the Japan Heart Foundation; a Pfizer Pharmaceuticals Grant for Research on Coronary Artery Disease; a Research Grant of the Tokyo Hypertension Conference; and a Research Grant of Sankyo Foundation of Life Science (to H. Morita).
Weitere Informationen
Publikationsverlauf
Received
03. November 1999
Accepted after resubmission
29. Februar 2000
Publikationsdatum:
10. Dezember 2017 (online)
Summary
We examined the relationship between plasma homocysteine levels and restenosis after PTCA (Percutaneous transluminal coronary angioplasty) to investigate whether plasma homocysteine levels can be a predictor of restenosis after PTCA. One hundred and twelve male patients who have undergone a successful elective PTCA were consecutively enrolled and plasma homocysteine levels were measured at the time of follow-up angiography. Plasma homocysteine levels in patients with restenosis were significantly higher than those in patients without restenosis (15.0 ± 3.9 vs. 13 ± 2.9 µmol/L; P = 0.011). The difference was augmented when diabetic patients were selectively studied. The comparison between restenosis group and non-restenosis group indicated the threshold effect of hyperhomocysteinemia. These results suggest that plasma homocysteine is a potential risk factor of restenosis after PTCA, and therapeutic strategy targeted against hyperhomocysteinemia may be beneficial for preventing restenosis.
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