Effect of Strenuous Arm Exercise on Oxidized-LDL-Potentiated Platelet Activation in Individuals with Spinal Cord Injury

Jong-Shyan Wang; Chih Fang Yang; May-Kuen Wong; Shu-Er Chow; Jan-Kan Chen

doi:10.1055/s-0037-1613978

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2000; 84(01): 118-123
DOI: 10.1055/s-0037-1613978

Commentary

Schattauer GmbH

Effect of Strenuous Arm Exercise on Oxidized-LDL-Potentiated Platelet Activation in Individuals with Spinal Cord Injury

Jong-Shyan Wang

³From the Department of Physical Therapy, Chang Gung University, Taoyuan, Taiwan

,

Chih Fang Yang

¹Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Taoyuan, Taiwan

,

May-Kuen Wong

¹Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Taoyuan, Taiwan

,

Shu-Er Chow

²Department of Physiology, Chang Gung University, Taoyuan, Taiwan

,

Jan-Kan Chen

²Department of Physiology, Chang Gung University, Taoyuan, Taiwan

› Author Affiliations

Abstract

Summary

This study investigates how strenuous arm exercise affects oxidizedlow density lipoprotein (Ox-LDL) mediated-platelet activation in patients with SCI. Ten patients with SCI and ten age- and sex-matched healthy subjects exercised strenuously using an arm crank ergometer. The following measurements were taken both when the subjects were at rest, and immediately after exercise: plasma lipid profile, Ox-LDL mediated platelet aggregability and [Ca²⁺]_i, urinary 11-dehydro-thromboxane B₂ (11-dehydro-TXB₂) and 8-iso-prostaglandin F_2α. (8-iso-PG F_2α.) contents, and plasma NO metabolite (nitrite plus nitrate) level. Based on these measurements, the major findings of this study can be summarized as follows: 1) the SCI group had higher urinary 8-iso- PGF_2α. and 11-dehydro-TXB₂ contents, but a lower plasma nitrite plus nitrate level than the control group; 2) at rest, the SCI group had a higher platelet aggregability and [Ca²⁺]_i, and Ox-LDL-potentiated platelet activation than the control group; 3) Ox-LDL-potentiated platelet aggregation was enhanced by strenuous arm exercise in both groups, but the effect of exercise was more pronounced in the SCI group than in the control group; 4) treating the platelet with L-arginine inhibited Ox-LDL-potentiated platelet activation in both groups. The study concludes that individuals with SCI had more extensive resting and exercise-enhanced Ox-LDL-potentiated platelet activation and greater amounts of preformed lipid peroxides than those without SCI. Therefore, supplementation therapy with antioxidants may be needed for patients with SCI, especially in a strenuous arm exercise period.

Key words

SCI - exercise - platelet - nitric oxide - Ox-LDL

Full Text

References

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