The C536T Transition in the Tissue Factor Pathway Inhibitor (TFPI) Gene Does not Contribute to Risk of Venous Thrombosis among Carriers of Factor V Leiden

Martin J. Hessner; Robert A. Luhm

doi:10.1055/s-0037-1614095

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2000; 84(04): 724-725
DOI: 10.1055/s-0037-1614095

Letters to the Editor

Schattauer GmbH

The C536T Transition in the Tissue Factor Pathway Inhibitor (TFPI) Gene Does not Contribute to Risk of Venous Thrombosis among Carriers of Factor V Leiden

Authors

Martin J. Hessner

¹From the Diagnostic Laboratories of The Blood Center, Milwaukee, WI. USA
Robert A. Luhm

¹From the Diagnostic Laboratories of The Blood Center, Milwaukee, WI. USA

Abstract

Full Text

References

References
1 Koeleman BPC, Reitsma PH, Allaart CF, Bertina RM. Activated protein resistance as an additional risk factor for thrombosis in protein C deficient families. Blood 1994; 84: 1031-5.
2 Zoller B, Berntsdotte A, Garcia Pde Frutos, Dahlback B. Resistance to activated protein C as an additional risk factor in hereditary deficiency of proteins. Blood 1995; 85: 3518-23.
3 Cattaneo M, Tsai MY, Bucciarelli P, Taioli E, Zighetti ML, Bignell M, Mannucci PM. A common mutation in the methylenetetrahydrofolate reductase gene (C677T) increases risk for deep-vein thrombosis in patients with mutant factor V (factor V:Q⁵⁰⁶) Arterioscler. Thromb Vase Biol 1997; 17: 1662-6.
4 Hessner MJ, Dinauer DM, Luhm RA, Endres JL, Montgomery RR, Friedman KD. The prothrombin 20210GA genotype acts as a cooperative risk factor for venous thrombosis among factor V 1691GA (Leiden) carriers. Br JHaemat 1999; 106: 237-9.
5 Girard TJ, Eddy R, Wesselschmidt RL, MacPhail LA, Likert KM, Byers MG, Shows TB, Broze GJ. Structure of the human lipoprotein-associated coagulation inhibitor gene Intron/exon gene organization and localization of the gene to chromosome 2. J Biol Chem 1991; 266: 5036-41.
6 van der Logt CP, Reitsma PH, Bertina RM. Intron/exon organization of the human gene coding for the lipoprotein-associated coagulation inhibitor: the factor Xa dependent inhibitor of the extrinsic pathway of coagulation. Biochemistry 1991; 30: 1571-7.
7 Kleesiek K, Schmidt M, Getting C, Schwenz B, Lange S, Muller-Berghaus G, Brinkman T, Prohaska W. The 536 C→T transition in the human tissue factor pathway inhibitor (TFPI) gene is statistically associated with a higher risk for venous thrombosis. Thromb Haemost 1999; 82: 1-5.
8 Hessner MJ, Luhm RA, Pearson SL, Endean DJ, Friedman KD, Montgomery RR. Prevalence of prothrombin G202010A, factor V G1691A (Leiden), and methylenetetrahydrofolate reductase (MTHFR) C677T in seven different populations determined by multiplex allele-specific PCR. Thromb Haemost 1999; 81: 733-8.